Yang, Q., Song, D., Xie, Z., He, G., Zhao, J., Wang, Z., Dong, Z., Zhang, H., Yang, L., Jiang, M., Wu, Y., Shi, Q., Li, J., Yang, J., Bai, Z., Quan, Z., & Qing, H. (2022). Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice. Progress in Neurobiology, 209, Article 102209. https://doi.org/10.1016/j.pneurobio.2021.102209
Yang, Qinghu ; Song, Da ; Xie, Zhen et al. / Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice. In: Progress in Neurobiology. 2022 ; Vol. 209.
@article{34ec140e2cc64b3f973b9f952fc515b2,
title = "Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice",
abstract = "The hippocampal CA3 region, that is involved in the encoding and retrieval of spatial memory, is found to be synaptically impaired in the early-onset of Alzheimer's disease (AD). It is reported optogenetic manipulation of DG or CA1 can rescue the memory impairment of APP/PS1 mice, however, how CA3 region contributes to AD-related deficits in cognitive function is still unknown. Our work shows optogenetic stimulation of CA3 pyramidal neurons (PNs) significantly restores the impaired spatial short-term memory of APP/PS1 mice. This enhances the anatomical synaptic density/strength and synaptic plasticity as well as activates astrocytes. Chemogenetic inhibiting the activity of CA3 astrocytes reverses the effect of optogenetic stimulation of CA3 PNs that leads to reduced anatomical synaptic density/strength, decreased synaptic protein and AMPA receptors GluA3/4, thus disrupting the cognitive restoration of APP/PS1 mice. These results reveal the molecular mechanism of optogenetic activation of CA3 PNs on restoration of the spatial short-term memory of APP/PS1 mice and unveil a potential strategy of manipulating CA3 for AD treatment.",
keywords = "Alzheimer's disease, Astrocytes, CA3, Optogenetics, Spatial memory, Synaptic plasticity",
author = "Qinghu Yang and Da Song and Zhen Xie and Guiqiong He and Juan Zhao and Zhe Wang and Zhifang Dong and Heao Zhang and Liang Yang and Ming Jiang and Yili Wu and Qing Shi and Junjie Li and Jun Yang and Zhantao Bai and Zhenzhen Quan and Hong Qing",
note = "Publisher Copyright: {\textcopyright} 2021",
year = "2022",
month = feb,
doi = "10.1016/j.pneurobio.2021.102209",
language = "English",
volume = "209",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "Elsevier Ltd.",
}
Yang, Q, Song, D, Xie, Z, He, G, Zhao, J, Wang, Z, Dong, Z, Zhang, H, Yang, L, Jiang, M, Wu, Y, Shi, Q, Li, J, Yang, J, Bai, Z, Quan, Z & Qing, H 2022, 'Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice', Progress in Neurobiology, vol. 209, 102209. https://doi.org/10.1016/j.pneurobio.2021.102209
Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice. / Yang, Qinghu; Song, Da; Xie, Zhen et al.
In:
Progress in Neurobiology, Vol. 209, 102209, 02.2022.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice
AU - Yang, Qinghu
AU - Song, Da
AU - Xie, Zhen
AU - He, Guiqiong
AU - Zhao, Juan
AU - Wang, Zhe
AU - Dong, Zhifang
AU - Zhang, Heao
AU - Yang, Liang
AU - Jiang, Ming
AU - Wu, Yili
AU - Shi, Qing
AU - Li, Junjie
AU - Yang, Jun
AU - Bai, Zhantao
AU - Quan, Zhenzhen
AU - Qing, Hong
N1 - Publisher Copyright:
© 2021
PY - 2022/2
Y1 - 2022/2
N2 - The hippocampal CA3 region, that is involved in the encoding and retrieval of spatial memory, is found to be synaptically impaired in the early-onset of Alzheimer's disease (AD). It is reported optogenetic manipulation of DG or CA1 can rescue the memory impairment of APP/PS1 mice, however, how CA3 region contributes to AD-related deficits in cognitive function is still unknown. Our work shows optogenetic stimulation of CA3 pyramidal neurons (PNs) significantly restores the impaired spatial short-term memory of APP/PS1 mice. This enhances the anatomical synaptic density/strength and synaptic plasticity as well as activates astrocytes. Chemogenetic inhibiting the activity of CA3 astrocytes reverses the effect of optogenetic stimulation of CA3 PNs that leads to reduced anatomical synaptic density/strength, decreased synaptic protein and AMPA receptors GluA3/4, thus disrupting the cognitive restoration of APP/PS1 mice. These results reveal the molecular mechanism of optogenetic activation of CA3 PNs on restoration of the spatial short-term memory of APP/PS1 mice and unveil a potential strategy of manipulating CA3 for AD treatment.
AB - The hippocampal CA3 region, that is involved in the encoding and retrieval of spatial memory, is found to be synaptically impaired in the early-onset of Alzheimer's disease (AD). It is reported optogenetic manipulation of DG or CA1 can rescue the memory impairment of APP/PS1 mice, however, how CA3 region contributes to AD-related deficits in cognitive function is still unknown. Our work shows optogenetic stimulation of CA3 pyramidal neurons (PNs) significantly restores the impaired spatial short-term memory of APP/PS1 mice. This enhances the anatomical synaptic density/strength and synaptic plasticity as well as activates astrocytes. Chemogenetic inhibiting the activity of CA3 astrocytes reverses the effect of optogenetic stimulation of CA3 PNs that leads to reduced anatomical synaptic density/strength, decreased synaptic protein and AMPA receptors GluA3/4, thus disrupting the cognitive restoration of APP/PS1 mice. These results reveal the molecular mechanism of optogenetic activation of CA3 PNs on restoration of the spatial short-term memory of APP/PS1 mice and unveil a potential strategy of manipulating CA3 for AD treatment.
KW - Alzheimer's disease
KW - Astrocytes
KW - CA3
KW - Optogenetics
KW - Spatial memory
KW - Synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=85122143866&partnerID=8YFLogxK
U2 - 10.1016/j.pneurobio.2021.102209
DO - 10.1016/j.pneurobio.2021.102209
M3 - Article
C2 - 34953962
AN - SCOPUS:85122143866
SN - 0301-0082
VL - 209
JO - Progress in Neurobiology
JF - Progress in Neurobiology
M1 - 102209
ER -
Yang Q, Song D, Xie Z, He G, Zhao J, Wang Z et al. Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice. Progress in Neurobiology. 2022 Feb;209:102209. doi: 10.1016/j.pneurobio.2021.102209
