Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

Qingqing Xiong; Yujing Li; Kun Zhou; Ping Chen; Hua Guo; Lu Chen; Jianxun Ding; Tianqiang Song; Jinjun Shi

doi:10.1039/c9bm01738k

Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

Qingqing Xiong, Yujing Li, Kun Zhou, Ping Chen, Hua Guo, Lu Chen, Jianxun Ding, Tianqiang Song, Jinjun Shi

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

Original language	English
Pages (from-to)	758-762
Number of pages	5
Journal	Biomaterials Science
Volume	8
Issue number	3
DOIs	https://doi.org/10.1039/c9bm01738k
Publication status	Published - 20 Feb 2020
Externally published	Yes

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10.1039/c9bm01738k

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title = "Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery",

abstract = "Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.",

author = "Qingqing Xiong and Yujing Li and Kun Zhou and Ping Chen and Hua Guo and Lu Chen and Jianxun Ding and Tianqiang Song and Jinjun Shi",

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T1 - Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

AU - Xiong, Qingqing

AU - Li, Yujing

AU - Zhou, Kun

AU - Chen, Ping

AU - Guo, Hua

AU - Chen, Lu

AU - Ding, Jianxun

AU - Song, Tianqiang

AU - Shi, Jinjun

PY - 2020/2/20

Y1 - 2020/2/20

N2 - Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

AB - Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

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U2 - 10.1039/c9bm01738k

DO - 10.1039/c9bm01738k

M3 - Article

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SN - 2047-4830

VL - 8

SP - 758

EP - 762

JO - Biomaterials Science

JF - Biomaterials Science

IS - 3

ER -

Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticles for efficient siRNA delivery

Abstract

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