NOA 81 fabricated microfluidic chip for SH-SY5Y cell culture

Rui Li, Xuefei Lv, Yulin Deng*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

Microfluidic chip has been an important tool for the study of life science, especially in cell biology researches. The chip provides precise manipulation of cells and helps establish similar environment in body network. A promising material, Noland Optical Adhesive 81 (NOA 81), was adopted here to fast fabricate the chip. The material was first cured and used for cell culture directly to test the biocompatibility and then fabricated into chips. We tested the flow influence on different designs of the chip structures. Finally, SH-SY5Y cells were induced and cultured in the microfluidic chip. The results show NOA 81 has good viabilities and adherence for cell culture. Column in chamber can reduce and disperse the fluid stress efficiently. With the efficient chip design, SH-SY5Y cells can survive in chip for more than one week.

Original languageEnglish
Title of host publication2015 IEEE International Conference on Mechatronics and Automation, ICMA 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages994-998
Number of pages5
ISBN (Electronic)9781479970964
DOIs
Publication statusPublished - 2 Sept 2015
Event12th IEEE International Conference on Mechatronics and Automation, ICMA 2015 - Beijing, China
Duration: 2 Aug 20155 Aug 2015

Publication series

Name2015 IEEE International Conference on Mechatronics and Automation, ICMA 2015

Conference

Conference12th IEEE International Conference on Mechatronics and Automation, ICMA 2015
Country/TerritoryChina
CityBeijing
Period2/08/155/08/15

Keywords

  • NOA 81
  • cell culture
  • microfluidic chip

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