Nitration reaction catalyzed by horseradish peroxidase in the presence of H2O2 and NaNO2

Rong Ji Dai*, Hui Huang, Jie Chen, Yu Lin Deng, Sheng Yuan Xiao

*Corresponding author for this work

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Abstract

The enzymatic nitration of phenol and m-cresol catalyzed by horseradish peroxidase was studied in the presence of H2O2 and NaNO2. The results showed that the nitration products of phenol were 2-nitro and 4-nitrophenols. There was also a small amount of by-products of hydroquinone and catechol. The influences of various reaction parameters, including pH, organic solvent type, and concentrations of NaNO2 and H2O2, on the nitration products were investigated. The yields of 4-nitrophenol and 2-nitrophenol were 14% and 12%, respectively. The nitration products of m-cresol were 4-nitro-m-cresol and 6-nitro-m-cresol, and the yields of 4-nitro-m-cresol and 6-nitro-m-cresol were 19% and 30%, respectively.

Original languageEnglish
Pages (from-to)1690-1694
Number of pages5
JournalChinese Journal of Chemistry
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Horseradish peroxidase
  • Nitration
  • Nitrophenol
  • Phenol

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Dai, R. J., Huang, H., Chen, J., Deng, Y. L., & Xiao, S. Y. (2007). Nitration reaction catalyzed by horseradish peroxidase in the presence of H2O2 and NaNO2. Chinese Journal of Chemistry, 25(11), 1690-1694. https://doi.org/10.1002/cjoc.200790312