TY - JOUR
T1 - Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis
AU - Tian, Guihua
AU - Wu, Chuanhong
AU - Li, Jian
AU - Liang, Bilin
AU - Zhang, Feilong
AU - Fan, Xingxing
AU - Li, Zewei
AU - Wang, Yongjun
AU - Li, Zhihong
AU - Liu, Di
AU - Lai-Han Leung, Elaine
AU - Chen, Jianxin
N1 - Publisher Copyright:
© 2019
PY - 2019/6
Y1 - 2019/6
N2 - Chronic atrophic gastritis (CAG) is a common digestive disease without specific treatment. According to syndrome differentiation, traditional Chinese medicine (TCM) classified it into different syndromes and has achieved significant therapeutic effects. In this study, immune repertoire sequencing techniques combined with symptom scores, electronic gastroscopy as well as pathologic changes were used to evaluate the effect and the underlying mechanism of Modified Sijunzi Decoction (MSD) in treating CAG. The results showed that MSD could relieve CAG symptoms, improve pathologic changes in CAG with fatigue and tiredness symptom, but with no help in CAG with reversal heat symptom. Moreover, MSD could regulate immune disorders in CAG with fatigue and tiredness symptom, and 7 TCR biomarkers were explored in CAG patients with immune disorders. All these results indicated that MSD is effective in treating CAG patients with fatigue and tiredness symptom by tonifying the spleen qi, suggesting that CAG treatment based on syndrome differentiation is reasonable.
AB - Chronic atrophic gastritis (CAG) is a common digestive disease without specific treatment. According to syndrome differentiation, traditional Chinese medicine (TCM) classified it into different syndromes and has achieved significant therapeutic effects. In this study, immune repertoire sequencing techniques combined with symptom scores, electronic gastroscopy as well as pathologic changes were used to evaluate the effect and the underlying mechanism of Modified Sijunzi Decoction (MSD) in treating CAG. The results showed that MSD could relieve CAG symptoms, improve pathologic changes in CAG with fatigue and tiredness symptom, but with no help in CAG with reversal heat symptom. Moreover, MSD could regulate immune disorders in CAG with fatigue and tiredness symptom, and 7 TCR biomarkers were explored in CAG patients with immune disorders. All these results indicated that MSD is effective in treating CAG patients with fatigue and tiredness symptom by tonifying the spleen qi, suggesting that CAG treatment based on syndrome differentiation is reasonable.
KW - Chronic atrophic gastritis
KW - Damp-heat syndrome
KW - Immune repertoire sequencing analysis
KW - Modified Sijunzi Decoction
KW - Spleen qi deficiency syndrome
UR - http://www.scopus.com/inward/record.url?scp=85064322679&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2019.04.012
DO - 10.1016/j.phrs.2019.04.012
M3 - Article
C2 - 30991106
AN - SCOPUS:85064322679
SN - 1043-6618
VL - 144
SP - 158
EP - 166
JO - Pharmacological Research
JF - Pharmacological Research
ER -