@inproceedings{4dcf434f9f284994a04edc1a60aadff7,
title = "Modular reconfiguration of metabolic brain networks in health and cancer: A resting-state PET study",
abstract = "Recent studies suggested that cognitive impairments and memory difficulties in cancer survivors were associated with topology changes of brain network, particularly in terms of the functional and structural abnormalities. However, little is known about the modular reconfiguration of metabolic brain network among this population. In this study, we recruited 78 patients with pre-treatment cancer and 80 age- and gender-matched normal controls (NCs), and constructed the metabolic brain networks derived from resting-state 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to assess the alters of modularity pattern in cancer. The measurements of the participation index (PI) and mutual information (MI) were calculated for the cancer and NC groups. Compared with NC group, one module composed by the hippocampus, the amygdala and frontal and temporal regions was absented in cancer group. Moreover, cancer patients showed abnormal topology pattern in their metabolic networks (i.e., increased local efficiency and reduced global efficiency). Although node-wise PI shared positive correlated with normalized metabolism uptake in both groups, the more energy consumption were observed in metabolism network of cancer group that might be indicative of reduced capability of information processing. In addition, the between-group MIs were gradually increased over a range of thresholds. Our results suggested that modular pattern of the metabolic brain network seemed to re-shape its organization in cancer, which might uncover the neurobiological mechanisms underlying cancer-related cognitive dysfunction.",
keywords = "Cancer, Modularity, Mutual information, PET, Participation index",
author = "Zhijun Yao and Bin Hu and Xuejiao Chen and Yuanwei Xie and Lei Fang",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 ; Conference date: 15-12-2016 Through 18-12-2016",
year = "2017",
month = jan,
day = "17",
doi = "10.1109/BIBM.2016.7822665",
language = "English",
series = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1040--1046",
editor = "Kevin Burrage and Qian Zhu and Yunlong Liu and Tianhai Tian and Yadong Wang and Hu, {Xiaohua Tony} and Qinghua Jiang and Jiangning Song and Shinichi Morishita and Kevin Burrage and Guohua Wang",
booktitle = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
address = "United States",
}
