@inproceedings{19999f36aea84636b93a7ccfb028f923,
title = "Modeling nuclear shape with boundary representation of object",
abstract = "The nucleus shape is of greatly importance for disease diagnosis and cell function. In this paper, a new model for nucleus shape is proposed to more accurately represent it, which mainly contains two components: boundary axis representation and weighted least-squares B-spline fitting. Boundary axis representation is achieved by segmenting the nuclear object extracted from original images into two parts with the major axis and recognizing the object boundary of each part. Then weighted least-squares B-spline fitting is employed to obtain two curves to represent the nucleus shape. Experiments and comparisons demonstrate the effectiveness of the proposed model. Moreover, outliers can be discarded by using weighted idea to remarkably improve the fitting accuracy.",
keywords = "B-spline interpolation, nuclear shapes, subcellular location",
author = "Shuliang Wang and Ying Li and Dakui Wang and Hanning Yuan",
note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015 ; Conference date: 09-11-2015 Through 12-11-2015",
year = "2015",
month = dec,
day = "16",
doi = "10.1109/BIBM.2015.7359760",
language = "English",
series = "Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "645--648",
editor = "Schapranow, {lng. Matthieu} and Jiayu Zhou and Hu, {Xiaohua Tony} and Bin Ma and Sanguthevar Rajasekaran and Satoru Miyano and Illhoi Yoo and Brian Pierce and Amarda Shehu and Gombar, {Vijay K.} and Brian Chen and Vinay Pai and Jun Huan",
booktitle = "Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015",
address = "United States",
}