Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivo microcirculation study

Lei Xi; Can Duan; Huikai Xie; Huabei Jiang

doi:10.1364/AO.52.001928

Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivo microcirculation study

Lei Xi, Can Duan, Huikai Xie, Huabei Jiang^*

^*Corresponding author for this work

University of Florida

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Photoacoustic microscopy (PAM) is sensitive to optical absorption, while optical coherence tomography (OCT) is based on optical backscattering. Combining PAM and OCT can provide complementary information about biological tissue.Here we present a combined optical-resolution PAM(ORPAM) and OCT system that is integrated through a miniature probe with an overall diameter of 2.3 mm, suitable for insertion through a standard endoscopic or laparoscopic port during minimally invasive surgery or endoscopic exam. The hybrid probe consists of a common optical path for OCT (light delivery/detection) and ORPAM (light excitation) and a 10 MHz unfocused ultrasound transducer for photoacoustic detection. The combined system yields a lateral resolution of 15 μm for both ORPAM and OCT.

Original language	English
Pages (from-to)	1928-1931
Number of pages	4
Journal	Applied Optics
Volume	52
Issue number	9
DOIs	https://doi.org/10.1364/AO.52.001928
Publication status	Published - 20 Mar 2013
Externally published	Yes

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abstract = "Photoacoustic microscopy (PAM) is sensitive to optical absorption, while optical coherence tomography (OCT) is based on optical backscattering. Combining PAM and OCT can provide complementary information about biological tissue.Here we present a combined optical-resolution PAM(ORPAM) and OCT system that is integrated through a miniature probe with an overall diameter of 2.3 mm, suitable for insertion through a standard endoscopic or laparoscopic port during minimally invasive surgery or endoscopic exam. The hybrid probe consists of a common optical path for OCT (light delivery/detection) and ORPAM (light excitation) and a 10 MHz unfocused ultrasound transducer for photoacoustic detection. The combined system yields a lateral resolution of 15 μm for both ORPAM and OCT.",

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AB - Photoacoustic microscopy (PAM) is sensitive to optical absorption, while optical coherence tomography (OCT) is based on optical backscattering. Combining PAM and OCT can provide complementary information about biological tissue.Here we present a combined optical-resolution PAM(ORPAM) and OCT system that is integrated through a miniature probe with an overall diameter of 2.3 mm, suitable for insertion through a standard endoscopic or laparoscopic port during minimally invasive surgery or endoscopic exam. The hybrid probe consists of a common optical path for OCT (light delivery/detection) and ORPAM (light excitation) and a 10 MHz unfocused ultrasound transducer for photoacoustic detection. The combined system yields a lateral resolution of 15 μm for both ORPAM and OCT.

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Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivo microcirculation study

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