Mild, efficient, and selective cleavage of trityl ethers with antimony trichloride

Qinpei Wu; Yuan Wang; Wei Chen; Hua Liu

doi:10.1080/00397910500522041

Mild, efficient, and selective cleavage of trityl ethers with antimony trichloride

Qinpei Wu^*, Yuan Wang, Wei Chen, Hua Liu

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Selective detritylation is quite crucial in synthetic chemistry. A mild and efficient procedure for selective hydrolysis of trityl ethers in the presence of other frequently used hydroxy protecting groups: TBDPS, Bz, Bn, Ac and Ts with antimony trichloride was described and 5′-trityl uridine was detritylated smoothly too.

Original language	English
Pages (from-to)	1361-1366
Number of pages	6
Journal	Synthetic Communications
Volume	36
Issue number	10
DOIs	https://doi.org/10.1080/00397910500522041
Publication status	Published - 2006

Keywords

Antimony
Catalysis
Hydrolysis
Lewis acid
Protecting groups
Trityl ether

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10.1080/00397910500522041

Cite this

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title = "Mild, efficient, and selective cleavage of trityl ethers with antimony trichloride",

abstract = "Selective detritylation is quite crucial in synthetic chemistry. A mild and efficient procedure for selective hydrolysis of trityl ethers in the presence of other frequently used hydroxy protecting groups: TBDPS, Bz, Bn, Ac and Ts with antimony trichloride was described and 5′-trityl uridine was detritylated smoothly too.",

keywords = "Antimony, Catalysis, Hydrolysis, Lewis acid, Protecting groups, Trityl ether",

author = "Qinpei Wu and Yuan Wang and Wei Chen and Hua Liu",

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T1 - Mild, efficient, and selective cleavage of trityl ethers with antimony trichloride

AU - Wu, Qinpei

AU - Wang, Yuan

AU - Chen, Wei

AU - Liu, Hua

PY - 2006

Y1 - 2006

N2 - Selective detritylation is quite crucial in synthetic chemistry. A mild and efficient procedure for selective hydrolysis of trityl ethers in the presence of other frequently used hydroxy protecting groups: TBDPS, Bz, Bn, Ac and Ts with antimony trichloride was described and 5′-trityl uridine was detritylated smoothly too.

AB - Selective detritylation is quite crucial in synthetic chemistry. A mild and efficient procedure for selective hydrolysis of trityl ethers in the presence of other frequently used hydroxy protecting groups: TBDPS, Bz, Bn, Ac and Ts with antimony trichloride was described and 5′-trityl uridine was detritylated smoothly too.

KW - Antimony

KW - Catalysis

KW - Hydrolysis

KW - Lewis acid

KW - Protecting groups

KW - Trityl ether

UR - http://www.scopus.com/inward/record.url?scp=33645570880&partnerID=8YFLogxK

U2 - 10.1080/00397910500522041

DO - 10.1080/00397910500522041

M3 - Article

AN - SCOPUS:33645570880

SN - 0039-7911

VL - 36

SP - 1361

EP - 1366

JO - Synthetic Communications

JF - Synthetic Communications

IS - 10

ER -

Mild, efficient, and selective cleavage of trityl ethers with antimony trichloride

Abstract

Keywords

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