Microwave-assisted synthesis of 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones catalyzed by DBU in aqueous medium

Liupan Yang, Daxin Shi, Shu Chen, Hongxin Chai, Danfei Huang, Qi Zhang, Jiarong Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

A clean green, efficient and facile protocol was developed for the synthesis of a series of 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones in water with good yield by the reaction of 2-amino-nicotinonitriles with carbonyls catalyzed by DBU under microwave irradiation. The DBU–H2O system can be recycled five times without activity loss.

Original languageEnglish
Pages (from-to)945-951
Number of pages7
JournalGreen Chemistry
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 2012

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