Microvalve controlled multi-functional microfluidic chip for divisional cell co-culture

Rui Li; Xingjian Zhang; Xuefei Lv; Lina Geng; Yongrui Li; Kuiwei Qin; Yulin Deng

doi:10.1016/j.ab.2017.10.008

Microvalve controlled multi-functional microfluidic chip for divisional cell co-culture

Rui Li, Xingjian Zhang, Xuefei Lv, Lina Geng, Yongrui Li, Kuiwei Qin, Yulin Deng^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Pneumatic micro-valve controlled microfluidic chip provides precise fluidic control for cell manipulation. In this paper, a multi-functional microfluidic chip was designed for three separate experiments: 1. Different cell lines were dispensed and cultured; 2. Three transfected SH-SY5Y cells were introduced and treated with methyl-phenyl-pyridinium (MPP⁺) as drug delivery mode; 3. Specific protection and interaction were observed among cell co-culture after nerve damage. The outcomes revealed the potential and practicability of our entire multi-functional pneumatic chip system on different cell biology applications.

Original language	English
Pages (from-to)	48-53
Number of pages	6
Journal	Analytical Biochemistry
Volume	539
DOIs	https://doi.org/10.1016/j.ab.2017.10.008
Publication status	Published - 15 Dec 2017

Keywords

Cell culture
Drug stimulate
Microfluidic chip
Pneumatic microvalve

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10.1016/j.ab.2017.10.008

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abstract = "Pneumatic micro-valve controlled microfluidic chip provides precise fluidic control for cell manipulation. In this paper, a multi-functional microfluidic chip was designed for three separate experiments: 1. Different cell lines were dispensed and cultured; 2. Three transfected SH-SY5Y cells were introduced and treated with methyl-phenyl-pyridinium (MPP+) as drug delivery mode; 3. Specific protection and interaction were observed among cell co-culture after nerve damage. The outcomes revealed the potential and practicability of our entire multi-functional pneumatic chip system on different cell biology applications.",

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AU - Geng, Lina

AU - Li, Yongrui

AU - Qin, Kuiwei

AU - Deng, Yulin

PY - 2017/12/15

Y1 - 2017/12/15

N2 - Pneumatic micro-valve controlled microfluidic chip provides precise fluidic control for cell manipulation. In this paper, a multi-functional microfluidic chip was designed for three separate experiments: 1. Different cell lines were dispensed and cultured; 2. Three transfected SH-SY5Y cells were introduced and treated with methyl-phenyl-pyridinium (MPP+) as drug delivery mode; 3. Specific protection and interaction were observed among cell co-culture after nerve damage. The outcomes revealed the potential and practicability of our entire multi-functional pneumatic chip system on different cell biology applications.

AB - Pneumatic micro-valve controlled microfluidic chip provides precise fluidic control for cell manipulation. In this paper, a multi-functional microfluidic chip was designed for three separate experiments: 1. Different cell lines were dispensed and cultured; 2. Three transfected SH-SY5Y cells were introduced and treated with methyl-phenyl-pyridinium (MPP+) as drug delivery mode; 3. Specific protection and interaction were observed among cell co-culture after nerve damage. The outcomes revealed the potential and practicability of our entire multi-functional pneumatic chip system on different cell biology applications.

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KW - Drug stimulate

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Microvalve controlled multi-functional microfluidic chip for divisional cell co-culture

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Keywords

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