Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review

Zerong Liao; Yang Zhang; Yongrui Li; Yunfei Miao; Shimeng Gao; Fankai Lin; Yulin Deng; Lina Geng

doi:10.1016/j.bios.2018.11.032

Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review

Zerong Liao, Yang Zhang, Yongrui Li, Yunfei Miao, Shimeng Gao, Fankai Lin, Yulin Deng, Lina Geng^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

164 Citations (Scopus)

Abstract

This article reviews the recent advances in microfluidic-chip integrated optical biosensors for simultaneous detection of multiple analytes. In particular, the principles and recent progress in different kinds of multiplex optical biosensors and their biological application were reviewed comprehensively. Sensors based on multiplexed detection have absolute advantages in analysis throughput than single assay. The microfluidic chip, a type of micro-total analysis system (µTAS), provides an ideal platform for integration of high-throughput biosensors. Compared with electronic biosensors, benefitted from the technical development in Micro-Electro-Mechanical System, there have been greater advances in the fabrication of optical sensors and microfluidic chip, and then promoting microfluidic-chip integrated optical biosensors for simultaneous detection of multiple analytes.

Original language	English
Pages (from-to)	697-706
Number of pages	10
Journal	Biosensors and Bioelectronics
Volume	126
DOIs	https://doi.org/10.1016/j.bios.2018.11.032
Publication status	Published - 1 Feb 2019

Keywords

Microfluidic chip
Multiplex detection
Optical sensor

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10.1016/j.bios.2018.11.032

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title = "Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review",

abstract = "This article reviews the recent advances in microfluidic-chip integrated optical biosensors for simultaneous detection of multiple analytes. In particular, the principles and recent progress in different kinds of multiplex optical biosensors and their biological application were reviewed comprehensively. Sensors based on multiplexed detection have absolute advantages in analysis throughput than single assay. The microfluidic chip, a type of micro-total analysis system (µTAS), provides an ideal platform for integration of high-throughput biosensors. Compared with electronic biosensors, benefitted from the technical development in Micro-Electro-Mechanical System, there have been greater advances in the fabrication of optical sensors and microfluidic chip, and then promoting microfluidic-chip integrated optical biosensors for simultaneous detection of multiple analytes.",

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author = "Zerong Liao and Yang Zhang and Yongrui Li and Yunfei Miao and Shimeng Gao and Fankai Lin and Yulin Deng and Lina Geng",

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doi = "10.1016/j.bios.2018.11.032",

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AU - Liao, Zerong

AU - Zhang, Yang

AU - Li, Yongrui

AU - Miao, Yunfei

AU - Gao, Shimeng

AU - Lin, Fankai

AU - Deng, Yulin

AU - Geng, Lina

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AB - This article reviews the recent advances in microfluidic-chip integrated optical biosensors for simultaneous detection of multiple analytes. In particular, the principles and recent progress in different kinds of multiplex optical biosensors and their biological application were reviewed comprehensively. Sensors based on multiplexed detection have absolute advantages in analysis throughput than single assay. The microfluidic chip, a type of micro-total analysis system (µTAS), provides an ideal platform for integration of high-throughput biosensors. Compared with electronic biosensors, benefitted from the technical development in Micro-Electro-Mechanical System, there have been greater advances in the fabrication of optical sensors and microfluidic chip, and then promoting microfluidic-chip integrated optical biosensors for simultaneous detection of multiple analytes.

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KW - Optical sensor

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Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review

Abstract

Keywords

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