Metallo-supramolecular nanogels for intracellular pH-responsive drug release

Xuemei Yao; Li Chen; Xiaofei Chen; Chaoliang He; Jingping Zhang; Xuesi Chen

doi:10.1002/marc.201400291

Metallo-supramolecular nanogels for intracellular pH-responsive drug release

Xuemei Yao, Li Chen^*, Xiaofei Chen, Chaoliang He, Jingping Zhang, Xuesi Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A simple process is developed to fabricate metallo-supramolecular nanogels (MSNs) by the metallo-supramolecular-coordinated interaction between histidine and iron-meso-tetraphenylporphin. MSNs are composed of histidine-modified dextran (DH) and iron-meso-tetraphenylporphin (Fe-Por) and exhibit excellent biocompatibility and stability. MSNs show pH responsiveness in the intracellular mildly acidic environment, which has great potential for acid-triggered drug release delivery. In vitro drug release profiles demonstrate that the pH-dependent disassembly of MSNs to histidine and Por results in a quicker release rate of loaded-DOX at pH 5.3, while at pH 7.4 MSNs could hinder the release of loaded-DOX due to the enhanced stability of MSNs.

Original language	English
Pages (from-to)	1697-1705
Number of pages	9
Journal	Macromolecular Rapid Communications
Volume	35
Issue number	19
DOIs	https://doi.org/10.1002/marc.201400291
Publication status	Published - 1 Oct 2014
Externally published	Yes

Keywords

Biocompatibility
Drug delivery
Metallosupromolecular nanogels
PH responsiveness

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10.1002/marc.201400291

Cite this

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title = "Metallo-supramolecular nanogels for intracellular pH-responsive drug release",

abstract = "A simple process is developed to fabricate metallo-supramolecular nanogels (MSNs) by the metallo-supramolecular-coordinated interaction between histidine and iron-meso-tetraphenylporphin. MSNs are composed of histidine-modified dextran (DH) and iron-meso-tetraphenylporphin (Fe-Por) and exhibit excellent biocompatibility and stability. MSNs show pH responsiveness in the intracellular mildly acidic environment, which has great potential for acid-triggered drug release delivery. In vitro drug release profiles demonstrate that the pH-dependent disassembly of MSNs to histidine and Por results in a quicker release rate of loaded-DOX at pH 5.3, while at pH 7.4 MSNs could hinder the release of loaded-DOX due to the enhanced stability of MSNs.",

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author = "Xuemei Yao and Li Chen and Xiaofei Chen and Chaoliang He and Jingping Zhang and Xuesi Chen",

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AU - Yao, Xuemei

AU - Chen, Li

AU - Chen, Xiaofei

AU - He, Chaoliang

AU - Zhang, Jingping

AU - Chen, Xuesi

PY - 2014/10/1

Y1 - 2014/10/1

N2 - A simple process is developed to fabricate metallo-supramolecular nanogels (MSNs) by the metallo-supramolecular-coordinated interaction between histidine and iron-meso-tetraphenylporphin. MSNs are composed of histidine-modified dextran (DH) and iron-meso-tetraphenylporphin (Fe-Por) and exhibit excellent biocompatibility and stability. MSNs show pH responsiveness in the intracellular mildly acidic environment, which has great potential for acid-triggered drug release delivery. In vitro drug release profiles demonstrate that the pH-dependent disassembly of MSNs to histidine and Por results in a quicker release rate of loaded-DOX at pH 5.3, while at pH 7.4 MSNs could hinder the release of loaded-DOX due to the enhanced stability of MSNs.

AB - A simple process is developed to fabricate metallo-supramolecular nanogels (MSNs) by the metallo-supramolecular-coordinated interaction between histidine and iron-meso-tetraphenylporphin. MSNs are composed of histidine-modified dextran (DH) and iron-meso-tetraphenylporphin (Fe-Por) and exhibit excellent biocompatibility and stability. MSNs show pH responsiveness in the intracellular mildly acidic environment, which has great potential for acid-triggered drug release delivery. In vitro drug release profiles demonstrate that the pH-dependent disassembly of MSNs to histidine and Por results in a quicker release rate of loaded-DOX at pH 5.3, while at pH 7.4 MSNs could hinder the release of loaded-DOX due to the enhanced stability of MSNs.

KW - Biocompatibility

KW - Drug delivery

KW - Metallosupromolecular nanogels

KW - PH responsiveness

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Metallo-supramolecular nanogels for intracellular pH-responsive drug release

Abstract

Keywords

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