Metal-organic frameworks-derived bimetallic nanozyme platform enhances cytotoxic effect of photodynamic therapy in hypoxic cancer cells

Xiao Han, Yang Li, Ying Zhou, Zeyu Song, Yulin Deng, Jieling Qin*, Zhenqi Jiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) is increasingly accepted as a cancer treatment because it can target the tumor precisely and treat it noninvasively. The therapeutic effect of PDT is generally affected by three parameters: the light, the photosensitizers (PSs), and the local oxygen, where the performance of the PSs with light is greatly affected by the availability of local oxygen. However, hypoxia is one of the typical characteristics of the microenvironment in solid tumors, which renders the efficacy of PDT in cancer treatment. Here, we introduced a novel nanozyme platform, which composed of metal-organic frameworks (MOF) derived materials and could directly load the PSs. The nanozyme could generate oxygen by catalyzing H2O2, which enhanced the production of reactive oxygen species (ROS) and resulted in an improved cytotoxic effect of the PSs. We showed that, especially under the hypoxic environment, this nanozyme could alleviate the hypoxic situation by generating oxygen in the H2O2 solution and further improved the therapeutic effect of PDT consequently. In conclusion, this nanozyme platform allows the loading of PSs with ease and can catalyze H2O2 to generate oxygen to enhance the effect of PDT for cancer treatment in both normoxic and hypoxic environments.

Original languageEnglish
Article number109646
JournalMaterials and Design
Volume204
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Hypoxic environments
  • Metal-organic frameworks
  • Nanozymes
  • Photodynamic therapy
  • Reactive oxygen species

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