TY - JOUR
T1 - Metal-organic frameworks-derived bimetallic nanozyme platform enhances cytotoxic effect of photodynamic therapy in hypoxic cancer cells
AU - Han, Xiao
AU - Li, Yang
AU - Zhou, Ying
AU - Song, Zeyu
AU - Deng, Yulin
AU - Qin, Jieling
AU - Jiang, Zhenqi
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/6
Y1 - 2021/6
N2 - Photodynamic therapy (PDT) is increasingly accepted as a cancer treatment because it can target the tumor precisely and treat it noninvasively. The therapeutic effect of PDT is generally affected by three parameters: the light, the photosensitizers (PSs), and the local oxygen, where the performance of the PSs with light is greatly affected by the availability of local oxygen. However, hypoxia is one of the typical characteristics of the microenvironment in solid tumors, which renders the efficacy of PDT in cancer treatment. Here, we introduced a novel nanozyme platform, which composed of metal-organic frameworks (MOF) derived materials and could directly load the PSs. The nanozyme could generate oxygen by catalyzing H2O2, which enhanced the production of reactive oxygen species (ROS) and resulted in an improved cytotoxic effect of the PSs. We showed that, especially under the hypoxic environment, this nanozyme could alleviate the hypoxic situation by generating oxygen in the H2O2 solution and further improved the therapeutic effect of PDT consequently. In conclusion, this nanozyme platform allows the loading of PSs with ease and can catalyze H2O2 to generate oxygen to enhance the effect of PDT for cancer treatment in both normoxic and hypoxic environments.
AB - Photodynamic therapy (PDT) is increasingly accepted as a cancer treatment because it can target the tumor precisely and treat it noninvasively. The therapeutic effect of PDT is generally affected by three parameters: the light, the photosensitizers (PSs), and the local oxygen, where the performance of the PSs with light is greatly affected by the availability of local oxygen. However, hypoxia is one of the typical characteristics of the microenvironment in solid tumors, which renders the efficacy of PDT in cancer treatment. Here, we introduced a novel nanozyme platform, which composed of metal-organic frameworks (MOF) derived materials and could directly load the PSs. The nanozyme could generate oxygen by catalyzing H2O2, which enhanced the production of reactive oxygen species (ROS) and resulted in an improved cytotoxic effect of the PSs. We showed that, especially under the hypoxic environment, this nanozyme could alleviate the hypoxic situation by generating oxygen in the H2O2 solution and further improved the therapeutic effect of PDT consequently. In conclusion, this nanozyme platform allows the loading of PSs with ease and can catalyze H2O2 to generate oxygen to enhance the effect of PDT for cancer treatment in both normoxic and hypoxic environments.
KW - Hypoxic environments
KW - Metal-organic frameworks
KW - Nanozymes
KW - Photodynamic therapy
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=85102474185&partnerID=8YFLogxK
U2 - 10.1016/j.matdes.2021.109646
DO - 10.1016/j.matdes.2021.109646
M3 - Article
AN - SCOPUS:85102474185
SN - 0264-1275
VL - 204
JO - Materials and Design
JF - Materials and Design
M1 - 109646
ER -