Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

Xiaolong Fu; Peifeng Wan; Peipei Li; Jinpeng Wang; Siwei Guo; Yuan Zhang; Yachun An; Chao Ye; Ziyi Liu; Jiangang Gao; Jianming Yang; Jiangang Fan; Renjie Chai

doi:10.3389/fncel.2021.692762

Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

Xiaolong Fu, Peifeng Wan, Peipei Li, Jinpeng Wang, Siwei Guo, Yuan Zhang, Yachun An, Chao Ye, Ziyi Liu, Jiangang Gao^*, Jianming Yang^*, Jiangang Fan^*, Renjie Chai^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

69 Citations (Scopus)

Abstract

Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems. In this article, we mainly introduce the main mechanism of ototoxicity induced by aminoglycosides. Genetic analysis showed that the susceptibility of aminoglycosides was attributable to mutations in mtDNA, especially A1555G and C1494T mutations in 12S rRNA. In addition, the overexpression of NMDA receptors and the formation of free radicals also play an important role. Understanding the mechanism of ototoxicity induced by aminoglycosides is helpful to develop new therapeutic methods to protect hearing. In this article, the prevention methods of ototoxicity induced by aminoglycosides were introduced from the upstream and downstream aspects.

Original language	English
Article number	692762
Journal	Frontiers in Cellular Neuroscience
Volume	15
DOIs	https://doi.org/10.3389/fncel.2021.692762
Publication status	Published - 15 Jun 2021
Externally published	Yes

Keywords

aminoglycosides
hearing loss
mechanism
ototoxicity
prevention

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10.3389/fncel.2021.692762

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title = "Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides",

abstract = "Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems. In this article, we mainly introduce the main mechanism of ototoxicity induced by aminoglycosides. Genetic analysis showed that the susceptibility of aminoglycosides was attributable to mutations in mtDNA, especially A1555G and C1494T mutations in 12S rRNA. In addition, the overexpression of NMDA receptors and the formation of free radicals also play an important role. Understanding the mechanism of ototoxicity induced by aminoglycosides is helpful to develop new therapeutic methods to protect hearing. In this article, the prevention methods of ototoxicity induced by aminoglycosides were introduced from the upstream and downstream aspects.",

keywords = "aminoglycosides, hearing loss, mechanism, ototoxicity, prevention",

author = "Xiaolong Fu and Peifeng Wan and Peipei Li and Jinpeng Wang and Siwei Guo and Yuan Zhang and Yachun An and Chao Ye and Ziyi Liu and Jiangang Gao and Jianming Yang and Jiangang Fan and Renjie Chai",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Fu, Wan, Li, Wang, Guo, Zhang, An, Ye, Liu, Gao, Yang, Fan and Chai.",

year = "2021",

month = jun,

day = "15",

doi = "10.3389/fncel.2021.692762",

language = "English",

volume = "15",

journal = "Frontiers in Cellular Neuroscience",

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TY - JOUR

T1 - Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

AU - Fu, Xiaolong

AU - Wan, Peifeng

AU - Li, Peipei

AU - Wang, Jinpeng

AU - Guo, Siwei

AU - Zhang, Yuan

AU - An, Yachun

AU - Ye, Chao

AU - Liu, Ziyi

AU - Gao, Jiangang

AU - Yang, Jianming

AU - Fan, Jiangang

AU - Chai, Renjie

PY - 2021/6/15

Y1 - 2021/6/15

N2 - Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems. In this article, we mainly introduce the main mechanism of ototoxicity induced by aminoglycosides. Genetic analysis showed that the susceptibility of aminoglycosides was attributable to mutations in mtDNA, especially A1555G and C1494T mutations in 12S rRNA. In addition, the overexpression of NMDA receptors and the formation of free radicals also play an important role. Understanding the mechanism of ototoxicity induced by aminoglycosides is helpful to develop new therapeutic methods to protect hearing. In this article, the prevention methods of ototoxicity induced by aminoglycosides were introduced from the upstream and downstream aspects.

AB - Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems. In this article, we mainly introduce the main mechanism of ototoxicity induced by aminoglycosides. Genetic analysis showed that the susceptibility of aminoglycosides was attributable to mutations in mtDNA, especially A1555G and C1494T mutations in 12S rRNA. In addition, the overexpression of NMDA receptors and the formation of free radicals also play an important role. Understanding the mechanism of ototoxicity induced by aminoglycosides is helpful to develop new therapeutic methods to protect hearing. In this article, the prevention methods of ototoxicity induced by aminoglycosides were introduced from the upstream and downstream aspects.

KW - aminoglycosides

KW - hearing loss

KW - mechanism

KW - ototoxicity

KW - prevention

UR - http://www.scopus.com/inward/record.url?scp=85109004108&partnerID=8YFLogxK

U2 - 10.3389/fncel.2021.692762

DO - 10.3389/fncel.2021.692762

M3 - Review article

AN - SCOPUS:85109004108

SN - 1662-5102

VL - 15

JO - Frontiers in Cellular Neuroscience

JF - Frontiers in Cellular Neuroscience

M1 - 692762

ER -

Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

Abstract

Keywords

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