TY - GEN
T1 - Magnetically-guided manipulation of microfiber for fabrication of porous cell scaffold
AU - Li, Xingfu
AU - Shi, Qing
AU - Wang, Huaping
AU - Sun, Tao
AU - Li, Jianing
AU - Yu, Ning
AU - Huang, Qiang
AU - Fukuda, Toshio
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - As one of the most promising substitutes for regenerative medicine, the pore cell scaffold attracts great attentions in tissue engineering recently. In this study, we apply microfiber to assemble this kind of porous structure based on magnetically-guided manipulation. The microfiber is fabricated by biocompatible and biodegradable alginate solution inside a microfluidic device. To feasibly manipulate the microfiber, homogeneous magnetic nanoparticles are encapsulated into the alginate solution to improve controllability. Simultaneously, an external magnetic force generated by a round permanent magnet is provided to attract the microfibers on a magnetized device composed by pure iron wire arrays and wax. To provide a bionic environment, the magnetized device has been fabricated to allow the generation of optimal pore structure with submillimeter size and high density. As preliminary results, we have achieved to fabricate a one-layer cell scaffold through magnetically-guided micromanipulation.
AB - As one of the most promising substitutes for regenerative medicine, the pore cell scaffold attracts great attentions in tissue engineering recently. In this study, we apply microfiber to assemble this kind of porous structure based on magnetically-guided manipulation. The microfiber is fabricated by biocompatible and biodegradable alginate solution inside a microfluidic device. To feasibly manipulate the microfiber, homogeneous magnetic nanoparticles are encapsulated into the alginate solution to improve controllability. Simultaneously, an external magnetic force generated by a round permanent magnet is provided to attract the microfibers on a magnetized device composed by pure iron wire arrays and wax. To provide a bionic environment, the magnetized device has been fabricated to allow the generation of optimal pore structure with submillimeter size and high density. As preliminary results, we have achieved to fabricate a one-layer cell scaffold through magnetically-guided micromanipulation.
KW - Magnetic microfiber
KW - Magnetically-guided micromanipulation
KW - Magnetized device
KW - Microfluidic device
KW - Porous cell scaffold
UR - http://www.scopus.com/inward/record.url?scp=84991250928&partnerID=8YFLogxK
U2 - 10.1109/ICMA.2016.7558945
DO - 10.1109/ICMA.2016.7558945
M3 - Conference contribution
AN - SCOPUS:84991250928
T3 - 2016 IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016
SP - 2419
EP - 2424
BT - 2016 IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 13th IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016
Y2 - 7 August 2016 through 10 August 2016
ER -