Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Fuxue Zhang; Bozhang Xia; Jiabei Sun; Yufei Wang; Jinjin Wang; Fengfei Xu; Junge Chen; Mei Lu; Xin Yao; Peter Timashev; Yuanyuan Zhang; Meiwan Chen; Jing Che; Fangzhou Li; Xing Jie Liang

doi:10.34133/2022/9808429

Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Fuxue Zhang, Bozhang Xia, Jiabei Sun, Yufei Wang, Jinjin Wang, Fengfei Xu, Junge Chen, Mei Lu, Xin Yao, Peter Timashev, Yuanyuan Zhang, Meiwan Chen, Jing Che, Fangzhou Li^*, Xing Jie Liang^*

^*Corresponding author for this work

Advanced Research Institute of Multidisciplinary Science

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Intelligent drug delivery system based on “stimulus-response” mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.

Original language	English
Article number	9808429
Journal	Research
Volume	2022
DOIs	https://doi.org/10.34133/2022/9808429
Publication status	Published - 2022

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10.34133/2022/9808429

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@article{a795938ee88a4cd8b6fa373fa5ad709b,

title = "Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation",

abstract = "Intelligent drug delivery system based on “stimulus-response” mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.",

author = "Fuxue Zhang and Bozhang Xia and Jiabei Sun and Yufei Wang and Jinjin Wang and Fengfei Xu and Junge Chen and Mei Lu and Xin Yao and Peter Timashev and Yuanyuan Zhang and Meiwan Chen and Jing Che and Fangzhou Li and Liang, {Xing Jie}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Fuxue Zhang et al.",

year = "2022",

doi = "10.34133/2022/9808429",

language = "English",

volume = "2022",

journal = "Research",

issn = "2096-5168",

publisher = "American Association for the Advancement of Science",

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TY - JOUR

T1 - Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

AU - Zhang, Fuxue

AU - Xia, Bozhang

AU - Sun, Jiabei

AU - Wang, Yufei

AU - Wang, Jinjin

AU - Xu, Fengfei

AU - Chen, Junge

AU - Lu, Mei

AU - Yao, Xin

AU - Timashev, Peter

AU - Zhang, Yuanyuan

AU - Chen, Meiwan

AU - Che, Jing

AU - Li, Fangzhou

AU - Liang, Xing Jie

PY - 2022

Y1 - 2022

N2 - Intelligent drug delivery system based on “stimulus-response” mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.

AB - Intelligent drug delivery system based on “stimulus-response” mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.

UR - http://www.scopus.com/inward/record.url?scp=85146416826&partnerID=8YFLogxK

U2 - 10.34133/2022/9808429

DO - 10.34133/2022/9808429

M3 - Review article

AN - SCOPUS:85146416826

SN - 2096-5168

VL - 2022

JO - Research

JF - Research

M1 - 9808429

ER -

Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Abstract

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