TY - JOUR
T1 - LINC01089 Inhibits Tumorigenesis and Epithelial–Mesenchymal Transition of Non-small Cell Lung Cancer via the miR-27a/SFRP1/Wnt/β-catenin Axis
AU - Li, Xingkai
AU - Lv, Fang
AU - Li, Fang
AU - Du, Minjun
AU - Liang, Yicheng
AU - Ju, Shaolong
AU - Liu, Zixu
AU - Zhou, Boxuan
AU - Wang, Bing
AU - Gao, Yushun
N1 - Publisher Copyright:
© Copyright © 2020 Li, Lv, Li, Du, Liang, Ju, Liu, Zhou, Wang and Gao.
PY - 2020/11/17
Y1 - 2020/11/17
N2 - Long noncoding RNAs (lncRNAs) have emerged as regulators of gene expression and play critical regulatory roles in diverse biological functions and diseases, including cancer. In this study, we report the downregulation of LINC01089 in non-small cell lung cancer (NSCLC) samples, relative to adjacent non-tumor tissues, and demonstrate its role in the inhibition of proliferation, migration, and epithelial–mesenchymal transition (EMT) of NSCLC cells. Mechanistic analysis indicates that LINC01089 acts as a sponge for miR-27a, regulating its expression in NSCLC. Interestingly, LINC01089 mediated the upregulation of SFRP1 expression by inhibiting the Wnt/β-catenin–EMT pathway and inhibiting the epithelial–mesenchymal transition of NSCLC via sponging miR-27a. Overall, our findings highlight LINC01089’s tumorigenic role and regulatory mechanism in NSCLC, thereby suggesting its potential as a therapeutic target for managing NSCLC.
AB - Long noncoding RNAs (lncRNAs) have emerged as regulators of gene expression and play critical regulatory roles in diverse biological functions and diseases, including cancer. In this study, we report the downregulation of LINC01089 in non-small cell lung cancer (NSCLC) samples, relative to adjacent non-tumor tissues, and demonstrate its role in the inhibition of proliferation, migration, and epithelial–mesenchymal transition (EMT) of NSCLC cells. Mechanistic analysis indicates that LINC01089 acts as a sponge for miR-27a, regulating its expression in NSCLC. Interestingly, LINC01089 mediated the upregulation of SFRP1 expression by inhibiting the Wnt/β-catenin–EMT pathway and inhibiting the epithelial–mesenchymal transition of NSCLC via sponging miR-27a. Overall, our findings highlight LINC01089’s tumorigenic role and regulatory mechanism in NSCLC, thereby suggesting its potential as a therapeutic target for managing NSCLC.
KW - EMT
KW - LINC01089
KW - SFRP1
KW - miR-27
KW - non-small cell lung cancer
UR - http://www.scopus.com/inward/record.url?scp=85097192432&partnerID=8YFLogxK
U2 - 10.3389/fonc.2020.532581
DO - 10.3389/fonc.2020.532581
M3 - Article
AN - SCOPUS:85097192432
SN - 2234-943X
VL - 10
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 532581
ER -
