Light-emitting diode-based illumination system for in vitro photodynamic therapy

Defu Chen; Huifen Zheng; Zhiyong Huang; Huiyun Lin; Zhidong Ke; Shusen Xie; Buhong Li

doi:10.1155/2012/920671

Light-emitting diode-based illumination system for in vitro photodynamic therapy

Defu Chen, Huifen Zheng, Zhiyong Huang, Huiyun Lin, Zhidong Ke, Shusen Xie, Buhong Li^*

^*Corresponding author for this work

Fujian Normal University

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

The aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source for in vitro photodynamic therapy (PDT). This illumination system includes a red LED array composed of 70LEDs centered at 643nm, an air-cooling unit, and a specific-designed case. The irradiance as a function of the irradiation distance between the LED array and the sample, the homogeneity and stability of irradiation, and the effect of long-time irradiation on culture medium temperature were characterized. Furthermore, the survival rate of the CNE1 cells that sensitized with 5-aminolevulinic acid after PDT treatment was evaluated to demonstrate the efficiency of the new LED-based illumination system. The obtained results show that the LED-based illumination system is a promising light source for in vitro PDT that performed in standard multiwell plate.

Original language	English
Article number	920671
Journal	International Journal of Photoenergy
Volume	2012
DOIs	https://doi.org/10.1155/2012/920671
Publication status	Published - 2012
Externally published	Yes

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Chen, D., Zheng, H., Huang, Z., Lin, H., Ke, Z., Xie, S., & Li, B. (2012). Light-emitting diode-based illumination system for in vitro photodynamic therapy. International Journal of Photoenergy, 2012, Article 920671. https://doi.org/10.1155/2012/920671

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abstract = "The aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source for in vitro photodynamic therapy (PDT). This illumination system includes a red LED array composed of 70LEDs centered at 643nm, an air-cooling unit, and a specific-designed case. The irradiance as a function of the irradiation distance between the LED array and the sample, the homogeneity and stability of irradiation, and the effect of long-time irradiation on culture medium temperature were characterized. Furthermore, the survival rate of the CNE1 cells that sensitized with 5-aminolevulinic acid after PDT treatment was evaluated to demonstrate the efficiency of the new LED-based illumination system. The obtained results show that the LED-based illumination system is a promising light source for in vitro PDT that performed in standard multiwell plate.",

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AU - Chen, Defu

AU - Zheng, Huifen

AU - Huang, Zhiyong

AU - Lin, Huiyun

AU - Ke, Zhidong

AU - Xie, Shusen

AU - Li, Buhong

PY - 2012

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AB - The aim of this study is to develop a light-emitting diode- (LED-) based illumination system that can be used as an alternative light source for in vitro photodynamic therapy (PDT). This illumination system includes a red LED array composed of 70LEDs centered at 643nm, an air-cooling unit, and a specific-designed case. The irradiance as a function of the irradiation distance between the LED array and the sample, the homogeneity and stability of irradiation, and the effect of long-time irradiation on culture medium temperature were characterized. Furthermore, the survival rate of the CNE1 cells that sensitized with 5-aminolevulinic acid after PDT treatment was evaluated to demonstrate the efficiency of the new LED-based illumination system. The obtained results show that the LED-based illumination system is a promising light source for in vitro PDT that performed in standard multiwell plate.

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Light-emitting diode-based illumination system for in vitro photodynamic therapy

Abstract

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