Layered double hydroxide-hemin nanocomposite as mimetic peroxidase and its application in sensing

Fang Ting Zhang; Xia Long; De Wen Zhang; Yi Lun Sun; Ying Lin Zhou; Yu Rong Ma; Li Min Qi; Xin Xiang Zhang

doi:10.1016/j.snb.2013.10.097

Layered double hydroxide-hemin nanocomposite as mimetic peroxidase and its application in sensing

Fang Ting Zhang, Xia Long, De Wen Zhang, Yi Lun Sun, Ying Lin Zhou^*, Yu Rong Ma, Li Min Qi, Xin Xiang Zhang

^*Corresponding author for this work

Peking University

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

A novel mimetic peroxidase, layered double hydroxide (LDH)-hemin nanocomposite, was first prepared by immobilizing hemin between the nanosheets of Fe-Ni LDH obtained through hydrothermal method. It showed an improved peroxidase-like activity to H₂O₂ compared with hemin alone, which was proved by UV-Vis spectroscopy and electrochemical measurements. The electrochemical sensor based on Fe-Ni LDH-hemin nanocomposite exhibited a fast response to H₂O₂ with good linear range of 1-240 μM, a detection limit of 0.3 μM based on a signal-to-noise ratio of 3 and high selectivity. It performed better than the sensors based on HRP and hemin which were prepared in the same conditions. The high performance of the sensor made LDH-hemin nanocomposite a promising mimetic peroxidase to replace natural enzymes.

Original language	English
Pages (from-to)	150-156
Number of pages	7
Journal	Sensors and Actuators, B: Chemical
Volume	192
DOIs	https://doi.org/10.1016/j.snb.2013.10.097
Publication status	Published - 2014
Externally published	Yes

Keywords

Electrochemical sensor
Fe-Ni layered double hydroxide
Hemin
Mimetic peroxidase

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10.1016/j.snb.2013.10.097

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title = "Layered double hydroxide-hemin nanocomposite as mimetic peroxidase and its application in sensing",

abstract = "A novel mimetic peroxidase, layered double hydroxide (LDH)-hemin nanocomposite, was first prepared by immobilizing hemin between the nanosheets of Fe-Ni LDH obtained through hydrothermal method. It showed an improved peroxidase-like activity to H2O2 compared with hemin alone, which was proved by UV-Vis spectroscopy and electrochemical measurements. The electrochemical sensor based on Fe-Ni LDH-hemin nanocomposite exhibited a fast response to H2O2 with good linear range of 1-240 μM, a detection limit of 0.3 μM based on a signal-to-noise ratio of 3 and high selectivity. It performed better than the sensors based on HRP and hemin which were prepared in the same conditions. The high performance of the sensor made LDH-hemin nanocomposite a promising mimetic peroxidase to replace natural enzymes.",

keywords = "Electrochemical sensor, Fe-Ni layered double hydroxide, Hemin, Mimetic peroxidase",

author = "Zhang, {Fang Ting} and Xia Long and Zhang, {De Wen} and Sun, {Yi Lun} and Zhou, {Ying Lin} and Ma, {Yu Rong} and Qi, {Li Min} and Zhang, {Xin Xiang}",

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doi = "10.1016/j.snb.2013.10.097",

language = "English",

volume = "192",

pages = "150--156",

journal = "Sensors and Actuators, B: Chemical",

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T1 - Layered double hydroxide-hemin nanocomposite as mimetic peroxidase and its application in sensing

AU - Zhang, Fang Ting

AU - Long, Xia

AU - Zhang, De Wen

AU - Sun, Yi Lun

AU - Zhou, Ying Lin

AU - Ma, Yu Rong

AU - Qi, Li Min

AU - Zhang, Xin Xiang

PY - 2014

Y1 - 2014

N2 - A novel mimetic peroxidase, layered double hydroxide (LDH)-hemin nanocomposite, was first prepared by immobilizing hemin between the nanosheets of Fe-Ni LDH obtained through hydrothermal method. It showed an improved peroxidase-like activity to H2O2 compared with hemin alone, which was proved by UV-Vis spectroscopy and electrochemical measurements. The electrochemical sensor based on Fe-Ni LDH-hemin nanocomposite exhibited a fast response to H2O2 with good linear range of 1-240 μM, a detection limit of 0.3 μM based on a signal-to-noise ratio of 3 and high selectivity. It performed better than the sensors based on HRP and hemin which were prepared in the same conditions. The high performance of the sensor made LDH-hemin nanocomposite a promising mimetic peroxidase to replace natural enzymes.

AB - A novel mimetic peroxidase, layered double hydroxide (LDH)-hemin nanocomposite, was first prepared by immobilizing hemin between the nanosheets of Fe-Ni LDH obtained through hydrothermal method. It showed an improved peroxidase-like activity to H2O2 compared with hemin alone, which was proved by UV-Vis spectroscopy and electrochemical measurements. The electrochemical sensor based on Fe-Ni LDH-hemin nanocomposite exhibited a fast response to H2O2 with good linear range of 1-240 μM, a detection limit of 0.3 μM based on a signal-to-noise ratio of 3 and high selectivity. It performed better than the sensors based on HRP and hemin which were prepared in the same conditions. The high performance of the sensor made LDH-hemin nanocomposite a promising mimetic peroxidase to replace natural enzymes.

KW - Electrochemical sensor

KW - Fe-Ni layered double hydroxide

KW - Hemin

KW - Mimetic peroxidase

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JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

Layered double hydroxide-hemin nanocomposite as mimetic peroxidase and its application in sensing

Abstract

Keywords

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