Large time behavior of solution to a fully parabolic chemotaxis-haptotaxis model in higher dimensions

Yifu Wang, Yuanyuan Ke*

*Corresponding author for this work

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Abstract

This paper deals with the chemotaxis-haptotaxis model of cancer invasion in a bounded smooth domain Ω⊂Rn with zero-flux boundary conditions, where χ, ξ and μ are positive parameters. It is shown that if μ/χ is suitably large then for all sufficiently smooth initial data, the associated initial-boundary-value problem possesses a unique global-in-time classical solution that is bounded in Ω×(0, ∞), and if the initial data w0 is small, w becomes asymptotically negligible. Moreover, we prove that when domain Ω is convex, (1μ,1μ,0) is globally asymptotically stable provided that u0≢0 and thereby extends the result of Hillen et al. (2013) [18] to the higher space dimensions.

Original languageEnglish
Pages (from-to)6960-6988
Number of pages29
JournalJournal of Differential Equations
Volume260
Issue number9
DOIs
Publication statusPublished - 5 May 2016

Keywords

  • Asymptotic stability
  • Cancer invasion
  • Chemotaxis
  • Haptotaxis

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Wang, Y., & Ke, Y. (2016). Large time behavior of solution to a fully parabolic chemotaxis-haptotaxis model in higher dimensions. Journal of Differential Equations, 260(9), 6960-6988. https://doi.org/10.1016/j.jde.2016.01.017