Abstract
Interleukin-1 receptor associated kinase 4 (IRAK4) plays a crucial role in signal transduction and regulation in the TLRs/IL-1R signaling pathway, coordinating multiple inflammatory pathways involving immune system activation, cytokine production, and cell proliferation and differentiation. IRAK4 is associated with the pathogenesis and progression of hematological malignancies, including myelodysplastic syndrome, acute myeloid leukemia, chronic lymphocytic leukemia, and lymphoma. Therefore, IRAK4 may serve as an effective therapeutic target for hematologic malignancies. This review summarizes the research advances in the structure and function of IRAK4, as well as its mechanism of action and therapeutic implications in hematological malignancies, aiming to provide insights into pathogenesis of related diseases and targeted therapy research.
| Translated title of the contribution | Research progress on the role and mechanism of IRAK4 in hematological malignancies |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 1094-1098 |
| Number of pages | 5 |
| Journal | Medical Journal of Chinese People's Liberation Army |
| Volume | 49 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sept 2024 |
| Externally published | Yes |