TY - JOUR
T1 - In silico screening and identification of deleterious missense SNPs along with their effects on CD-209 gene
T2 - An insight to CD-209 related-diseases
AU - Kakar, Mohib Ullah
AU - Matloob, Muhammad
AU - Dai, Rongji
AU - Deng, Yulin
AU - Ullah, Kifayat
AU - Kakar, Ihsan Ullah
AU - Khaliq, Ghulam
AU - Umer, Muhammad
AU - Bhutto, Zhoaib Ahmed
AU - Fazlani, Sarfarz Ali
AU - Mehboob, Muhammad Zubair
N1 - Publisher Copyright:
© 2021 Kakar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2021/2
Y1 - 2021/2
N2 - DC-SIGN receptor articulated by macrophages and dendritic cells is encoded by CD209 gene and plays a role to activate and proliferate the T-lymphocytes in response of virus attack. The dysfunctional activity of DC-SIGN receptor because of missense SNPs can lead to cause dengue haemorrhage fever, HIV-1 infection etc. Out of 11 transcripts of CD209, all missense SNPs of canonical transcript were retrieved from Ensembl database and evaluated by their deleteriousness by using Polyphen-2, PMut, SIFT, MutPred, PROVEAN and PhD-SNP together with stimulation of its complete 3D structure. 10 nsSNPs were chosen depending on both the significance value of nsSNP and their prediction among SNPs evaluating servers which are based on different algorithms. Moreover, the position and native role of 10 nsSNPs in wild 3D model has been described which assist to acknowledge their importance. This study urges the researcher's community to experimentally validate these SNPs and their association in causing the diseases like dengue fever, Tuberculosis etc.
AB - DC-SIGN receptor articulated by macrophages and dendritic cells is encoded by CD209 gene and plays a role to activate and proliferate the T-lymphocytes in response of virus attack. The dysfunctional activity of DC-SIGN receptor because of missense SNPs can lead to cause dengue haemorrhage fever, HIV-1 infection etc. Out of 11 transcripts of CD209, all missense SNPs of canonical transcript were retrieved from Ensembl database and evaluated by their deleteriousness by using Polyphen-2, PMut, SIFT, MutPred, PROVEAN and PhD-SNP together with stimulation of its complete 3D structure. 10 nsSNPs were chosen depending on both the significance value of nsSNP and their prediction among SNPs evaluating servers which are based on different algorithms. Moreover, the position and native role of 10 nsSNPs in wild 3D model has been described which assist to acknowledge their importance. This study urges the researcher's community to experimentally validate these SNPs and their association in causing the diseases like dengue fever, Tuberculosis etc.
UR - http://www.scopus.com/inward/record.url?scp=85102067107&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0247249
DO - 10.1371/journal.pone.0247249
M3 - Article
C2 - 33635927
AN - SCOPUS:85102067107
SN - 1932-6203
VL - 16
JO - PLoS ONE
JF - PLoS ONE
IS - 2 Febuary
M1 - e0247249
ER -
