HPLC-ESI-MSn identification and NMR characterization of glucosyloxybenzyl 2R-benzylmalate deriva-tives from Arundina graminifolia and their anti-liver fibrotic effects in vitro

Qingqing Liu; Feiyi Sun; Yulin Deng; Rongji Dai; Fang Lv

doi:10.3390/molecules24030525

HPLC-ESI-MSⁿ identification and NMR characterization of glucosyloxybenzyl 2R-benzylmalate deriva-tives from Arundina graminifolia and their anti-liver fibrotic effects in vitro

Qingqing Liu, Feiyi Sun, Yulin Deng, Rongji Dai, Fang Lv^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Four new glucosyloxybenzyl 2R-benzylmalate derivatives, named Arundinoside H (2), I (5), J (6), K (8) as well as four known compounds Arundinoside D (1), G (3), F (4), E (7) were isolated and characterized by a combination of chemical and spectroscopic methods, including HR-ESI-MS, 1D and 2D NMR experiments. Besides, 24 unreported compounds were inferred from ESI-MSⁿ data. The anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of lipopolysaccharide (LPS)-induced activation of rat hepatic stellate cells (HSC-T6). The result suggested Arundinosides D, H, F, I and K showed moderate inhibitory effects in vitro.

Original language	English
Journal	Molecules
Volume	24
Issue number	3
DOIs	https://doi.org/10.3390/molecules24030525
Publication status	Published - 31 Jan 2019

Keywords

Anti-liver fibrotic effects
Arundina graminifolia
Glucosyloxybenzyl 2R-benzylmalates
MS fragmentation pattern

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title = "HPLC-ESI-MSn identification and NMR characterization of glucosyloxybenzyl 2R-benzylmalate deriva-tives from Arundina graminifolia and their anti-liver fibrotic effects in vitro",

abstract = "Four new glucosyloxybenzyl 2R-benzylmalate derivatives, named Arundinoside H (2), I (5), J (6), K (8) as well as four known compounds Arundinoside D (1), G (3), F (4), E (7) were isolated and characterized by a combination of chemical and spectroscopic methods, including HR-ESI-MS, 1D and 2D NMR experiments. Besides, 24 unreported compounds were inferred from ESI-MSn data. The anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of lipopolysaccharide (LPS)-induced activation of rat hepatic stellate cells (HSC-T6). The result suggested Arundinosides D, H, F, I and K showed moderate inhibitory effects in vitro.",

keywords = "Anti-liver fibrotic effects, Arundina graminifolia, Glucosyloxybenzyl 2R-benzylmalates, MS fragmentation pattern",

author = "Qingqing Liu and Feiyi Sun and Yulin Deng and Rongji Dai and Fang Lv",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors.",

year = "2019",

month = jan,

day = "31",

doi = "10.3390/molecules24030525",

language = "English",

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journal = "Molecules",

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TY - JOUR

T1 - HPLC-ESI-MSn identification and NMR characterization of glucosyloxybenzyl 2R-benzylmalate deriva-tives from Arundina graminifolia and their anti-liver fibrotic effects in vitro

AU - Liu, Qingqing

AU - Sun, Feiyi

AU - Deng, Yulin

AU - Dai, Rongji

AU - Lv, Fang

PY - 2019/1/31

Y1 - 2019/1/31

N2 - Four new glucosyloxybenzyl 2R-benzylmalate derivatives, named Arundinoside H (2), I (5), J (6), K (8) as well as four known compounds Arundinoside D (1), G (3), F (4), E (7) were isolated and characterized by a combination of chemical and spectroscopic methods, including HR-ESI-MS, 1D and 2D NMR experiments. Besides, 24 unreported compounds were inferred from ESI-MSn data. The anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of lipopolysaccharide (LPS)-induced activation of rat hepatic stellate cells (HSC-T6). The result suggested Arundinosides D, H, F, I and K showed moderate inhibitory effects in vitro.

AB - Four new glucosyloxybenzyl 2R-benzylmalate derivatives, named Arundinoside H (2), I (5), J (6), K (8) as well as four known compounds Arundinoside D (1), G (3), F (4), E (7) were isolated and characterized by a combination of chemical and spectroscopic methods, including HR-ESI-MS, 1D and 2D NMR experiments. Besides, 24 unreported compounds were inferred from ESI-MSn data. The anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of lipopolysaccharide (LPS)-induced activation of rat hepatic stellate cells (HSC-T6). The result suggested Arundinosides D, H, F, I and K showed moderate inhibitory effects in vitro.

KW - Anti-liver fibrotic effects

KW - Arundina graminifolia

KW - Glucosyloxybenzyl 2R-benzylmalates

KW - MS fragmentation pattern

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U2 - 10.3390/molecules24030525

DO - 10.3390/molecules24030525

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SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

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HPLC-ESI-MSⁿ identification and NMR characterization of glucosyloxybenzyl 2R-benzylmalate deriva-tives from Arundina graminifolia and their anti-liver fibrotic effects in vitro

Abstract

Keywords

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