Highly efficient double-activation catalysts for the synthesis of ketone cyanohydrins

Fu Xue Chen; Xiaohua Liu; Bo Qin; Hui Zhou; Xiaoming Feng; Guolin Zhang

doi:10.1055/s-2004-831167

Highly efficient double-activation catalysts for the synthesis of ketone cyanohydrins

Fu Xue Chen, Xiaohua Liu, Bo Qin, Hui Zhou, Xiaoming Feng^*, Guolin Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Tertiary cyanohydrin trimethylsilyl ethers were synthesized in excellent chemical yields by using salen-Al complex (0.25 mol%) and N-oxide (0.5 mol%) without solvent at ambient temperature. The relationship between the ligand structure and catalyst efficiency is discussed. Preliminary mechanistic studies were carried out, and transition states were proposed accounting for the action of the double-activation catalysts.

Original language	English
Pages (from-to)	2266-2272
Number of pages	7
Journal	Synthesis
Issue number	14
DOIs	https://doi.org/10.1055/s-2004-831167
Publication status	Published - 1 Oct 2004
Externally published	Yes

Keywords

Addition reactions
Aluminum
Ketones
Nitriles
Schiff bases

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Cite this

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abstract = "Tertiary cyanohydrin trimethylsilyl ethers were synthesized in excellent chemical yields by using salen-Al complex (0.25 mol%) and N-oxide (0.5 mol%) without solvent at ambient temperature. The relationship between the ligand structure and catalyst efficiency is discussed. Preliminary mechanistic studies were carried out, and transition states were proposed accounting for the action of the double-activation catalysts.",

keywords = "Addition reactions, Aluminum, Ketones, Nitriles, Schiff bases",

author = "Chen, {Fu Xue} and Xiaohua Liu and Bo Qin and Hui Zhou and Xiaoming Feng and Guolin Zhang",

year = "2004",

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T1 - Highly efficient double-activation catalysts for the synthesis of ketone cyanohydrins

AU - Chen, Fu Xue

AU - Liu, Xiaohua

AU - Qin, Bo

AU - Zhou, Hui

AU - Feng, Xiaoming

AU - Zhang, Guolin

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Tertiary cyanohydrin trimethylsilyl ethers were synthesized in excellent chemical yields by using salen-Al complex (0.25 mol%) and N-oxide (0.5 mol%) without solvent at ambient temperature. The relationship between the ligand structure and catalyst efficiency is discussed. Preliminary mechanistic studies were carried out, and transition states were proposed accounting for the action of the double-activation catalysts.

AB - Tertiary cyanohydrin trimethylsilyl ethers were synthesized in excellent chemical yields by using salen-Al complex (0.25 mol%) and N-oxide (0.5 mol%) without solvent at ambient temperature. The relationship between the ligand structure and catalyst efficiency is discussed. Preliminary mechanistic studies were carried out, and transition states were proposed accounting for the action of the double-activation catalysts.

KW - Addition reactions

KW - Aluminum

KW - Ketones

KW - Nitriles

KW - Schiff bases

UR - http://www.scopus.com/inward/record.url?scp=5644292022&partnerID=8YFLogxK

U2 - 10.1055/s-2004-831167

DO - 10.1055/s-2004-831167

M3 - Article

AN - SCOPUS:5644292022

SN - 0039-7881

SP - 2266

EP - 2272

JO - Synthesis

JF - Synthesis

IS - 14

ER -

Highly efficient double-activation catalysts for the synthesis of ketone cyanohydrins

Abstract

Keywords

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