@inproceedings{31ad00aec4ed4214a993e7a775b845e5,
title = "High-Density Microneedle Array (HIDMA): An in vivo Electroporation Method for Low-Voltage Gene Delivery",
abstract = "In this work, we report a novel in vivo electroporation method for gene delivery utilizing high-density microneedle array (HIDMA). Owing to the minimized needle spacing, hexagonal distribution, and tri-polarity electric connection of the device, the low voltage and uniform electric field during electroporation can dramatically reduce cell damage and enhance delivery efficiency. The HIDMA is constructed with modified acupuncture needles, and can be customized for both superficial and deep tissues with different electroporation areas. According to the in vivo experiments on DNA plasmid delivery, our 0.6 and 1.2-mm-long microneedles with ∼ 5μm tips and 750μm pitch, can penetrate the outer skin to reduce the contact impedance that achieves effective electroporation within tens of volts and without obvious injury.",
keywords = "gene delivery, in vivo electroporation, low voltage, microneedle array",
author = "Junshi Li and Tangren Yang and Dong Huang and Yufeng Chen and Yuanyu Huang and Zhihong Li",
note = "Publisher Copyright: {\textcopyright} 2020 IEEE.; 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 ; Conference date: 18-01-2020 Through 22-01-2020",
year = "2020",
month = jan,
doi = "10.1109/MEMS46641.2020.9056145",
language = "English",
series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "372--375",
booktitle = "33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020",
address = "United States",
}