Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through a MEMS scanning mirror

Hao Yang, Lei Xi, Sean Samuelson, Huikai Xie, Lily Yang, Huabei Jiang*

*Corresponding author for this work

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Abstract

We describe a novel dual-modality imaging approach that integrates diffuse optical tomography (DOT) and photoacoustic imaging (PAI) through a miniaturized handheld probe based on microelectromechanical systems (MEMS) scanning mirror. We validate this dual-modal DOT/PAI approach using extensive phantom experiments, and demonstrate its application for tumor imaging using tumor-bearing mice systematically injected with targeted contrast agents.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalBiomedical Optics Express
Volume4
Issue number3
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • (110.6960) Tomography
  • (170.0110) Imaging systems
  • (170.5120) Photoacoustic imaging

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Yang, H., Xi, L., Samuelson, S., Xie, H., Yang, L., & Jiang, H. (2013). Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through a MEMS scanning mirror. Biomedical Optics Express, 4(3), 427-432. https://doi.org/10.1364/BOE.4.000427