Hair Cell Regeneration

Yan Chen; Shasha Zhang; Renjie Chai; Huawei Li

doi:10.1007/978-981-13-6123-4_1

Hair Cell Regeneration

Yan Chen, Shasha Zhang, Renjie Chai, Huawei Li^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

42 Citations (Scopus)

Abstract

Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss. Many regulatory factors, including signaling pathways, transcription factors, and epigenetic regulators, play roles in hair cell regeneration in various species. In this chapter, we review the history of hair cell regeneration research, the methods used in the study of hair cell regeneration, the properties and modulating factors of inner ear stem cells, and the re-formation of cochlear ribbon synapses and hearing function recovery.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer New York LLC
Pages	1-16
Number of pages	16
DOIs	https://doi.org/10.1007/978-981-13-6123-4_1
Publication status	Published - 2019
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1130
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Auditory system
Cochlea
Epigenetic regulation
Hair cell regeneration
Signaling pathways
Transcription factors

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10.1007/978-981-13-6123-4_1

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Chen, Y., Zhang, S., Chai, R., & Li, H. (2019). Hair Cell Regeneration. In Advances in Experimental Medicine and Biology (pp. 1-16). (Advances in Experimental Medicine and Biology; Vol. 1130). Springer New York LLC. https://doi.org/10.1007/978-981-13-6123-4_1

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author = "Yan Chen and Shasha Zhang and Renjie Chai and Huawei Li",

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AU - Chen, Yan

AU - Zhang, Shasha

AU - Chai, Renjie

AU - Li, Huawei

PY - 2019

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AB - Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss. Many regulatory factors, including signaling pathways, transcription factors, and epigenetic regulators, play roles in hair cell regeneration in various species. In this chapter, we review the history of hair cell regeneration research, the methods used in the study of hair cell regeneration, the properties and modulating factors of inner ear stem cells, and the re-formation of cochlear ribbon synapses and hearing function recovery.

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KW - Cochlea

KW - Epigenetic regulation

KW - Hair cell regeneration

KW - Signaling pathways

KW - Transcription factors

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Hair Cell Regeneration

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