Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

Yuexiao Jia; Jiangjiang Zhang; Yingcan Zhao; Ruihua Dong; Hui Wang; Xingyu Jiang

doi:10.1039/d2cc03460c

Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

Yuexiao Jia, Jiangjiang Zhang, Yingcan Zhao, Ruihua Dong, Hui Wang, Xingyu Jiang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We introduce N-acetyl-l-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.

Original language	English
Pages (from-to)	10544-10547
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	75
DOIs	https://doi.org/10.1039/d2cc03460c
Publication status	Published - 11 Aug 2022
Externally published	Yes

Access to Document

10.1039/d2cc03460c

Cite this

Jia, Y., Zhang, J., Zhao, Y., Dong, R., Wang, H., & Jiang, X. (2022). Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria. Chemical Communications, 58(75), 10544-10547. https://doi.org/10.1039/d2cc03460c

@article{60c7a57613694702a21b2da2825b90b0,

title = "Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria",

abstract = "We introduce N-acetyl-l-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.",

author = "Yuexiao Jia and Jiangjiang Zhang and Yingcan Zhao and Ruihua Dong and Hui Wang and Xingyu Jiang",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

month = aug,

day = "11",

doi = "10.1039/d2cc03460c",

language = "English",

volume = "58",

pages = "10544--10547",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "75",

}

TY - JOUR

T1 - Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

AU - Jia, Yuexiao

AU - Zhang, Jiangjiang

AU - Zhao, Yingcan

AU - Dong, Ruihua

AU - Wang, Hui

AU - Jiang, Xingyu

PY - 2022/8/11

Y1 - 2022/8/11

N2 - We introduce N-acetyl-l-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.

AB - We introduce N-acetyl-l-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide a new direction for antibiotic design and novel uses of known drugs.

UR - http://www.scopus.com/inward/record.url?scp=85138460901&partnerID=8YFLogxK

U2 - 10.1039/d2cc03460c

DO - 10.1039/d2cc03460c

M3 - Article

C2 - 36047304

AN - SCOPUS:85138460901

SN - 1359-7345

VL - 58

SP - 10544

EP - 10547

JO - Chemical Communications

JF - Chemical Communications

IS - 75

ER -

Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

Abstract

Access to Document

Other files and links

Fingerprint

Cite this