Abstract
A gold-catalyzed C(sp3)-C(sp2) Suzuki-Miyaura coupling reaction facilitated by ligand-enabled Au(I)/Au(III) redox catalysis was developed. The cross-coupling of alkyl organometallics was first realized in the redox catalytic cycle in gold chemistry, without the use of external oxidants. This gold-catalyzed C(sp3)-C(sp2) coupling reaction allows a variety of alkyl chain and useful methyl trifluoroborates to react with aryl and vinyl iodides under very mild conditions, which provides a new reactivity pattern for challenging couplings with alkyl organometallics.
Original language | English |
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Pages (from-to) | 3145-3150 |
Number of pages | 6 |
Journal | Organic Letters |
Volume | 26 |
Issue number | 15 |
DOIs | |
Publication status | Published - 19 Apr 2024 |
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Du, W., Zhao, F., Yang, R., & Xia, Z. (2024). Gold-Catalyzed C(sp3)-C(sp2) Suzuki-Miyaura Coupling Reaction. Organic Letters, 26(15), 3145-3150. https://doi.org/10.1021/acs.orglett.4c00755