Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome

Dongsheng Guo, Feima Wu, Haikun Liu, Ge Gao, Shanglong Kou, Fan Yang, Nasir Abbas, Tiancheng Zhou, Xiujuan Cai, Hui Zhang, Dajiang Qin, Jialiang Li, Kecheng Xu*, Yin xiong Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Urine resource cells were collected from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome (MEN1) for generating iPS cells with episomal plasmids. Two stable iPSC lines with free of episomal plasmid were established. The patient has a heterozygous G > T mutation on the exon 9 of Men1 gene that was confirmed by sequencing analysis on all resulted cell lines. Karyotyping indicated the chromosomes with normal appearances and numbers. Their pluripotency was demonstrated by gene expression and their abilities for differentiating into three germ layers. These iPSC lines provide valuable in vitro resources for pathological study on MEN1 syndrome.

Original languageEnglish
Pages (from-to)70-72
Number of pages3
JournalStem Cell Research
Volume18
DOIs
Publication statusPublished - Jan 2017
Externally publishedYes

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Guo, D., Wu, F., Liu, H., Gao, G., Kou, S., Yang, F., Abbas, N., Zhou, T., Cai, X., Zhang, H., Qin, D., Li, J., Xu, K., & Li, Y. X. (2017). Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome. Stem Cell Research, 18, 70-72. https://doi.org/10.1016/j.scr.2016.12.002