Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo

Tuo Wei; Juan Liu; Huili Ma; Qiang Cheng; Yuanyu Huang; Jing Zhao; Shuaidong Huo; Xiangdong Xue; Zicai Liang; Xing Jie Liang

doi:10.1021/nl400586t

Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo

Tuo Wei, Juan Liu, Huili Ma, Qiang Cheng, Yuanyu Huang, Jing Zhao, Shuaidong Huo, Xiangdong Xue, Zicai Liang, Xing Jie Liang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

183 Citations (Scopus)

Abstract

Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.

Original language	English
Pages (from-to)	2528-2534
Number of pages	7
Journal	Nano Letters
Volume	13
Issue number	6
DOIs	https://doi.org/10.1021/nl400586t
Publication status	Published - 12 Jun 2013
Externally published	Yes

Keywords

Targeted drug delivery
doxorubicin
micelle
neuropilin-1
tumor-penetrating peptide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/nl400586t

Cite this

@article{9bd0c4d9858f4107b2e2fad4a268d15a,

title = "Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo",

abstract = "Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.",

keywords = "Targeted drug delivery, doxorubicin, micelle, neuropilin-1, tumor-penetrating peptide",

author = "Tuo Wei and Juan Liu and Huili Ma and Qiang Cheng and Yuanyu Huang and Jing Zhao and Shuaidong Huo and Xiangdong Xue and Zicai Liang and Liang, {Xing Jie}",

year = "2013",

month = jun,

day = "12",

doi = "10.1021/nl400586t",

language = "English",

volume = "13",

pages = "2528--2534",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo

AU - Wei, Tuo

AU - Liu, Juan

AU - Ma, Huili

AU - Cheng, Qiang

AU - Huang, Yuanyu

AU - Zhao, Jing

AU - Huo, Shuaidong

AU - Xue, Xiangdong

AU - Liang, Zicai

AU - Liang, Xing Jie

PY - 2013/6/12

Y1 - 2013/6/12

N2 - Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.

AB - Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.

KW - Targeted drug delivery

KW - doxorubicin

KW - micelle

KW - neuropilin-1

KW - tumor-penetrating peptide

UR - http://www.scopus.com/inward/record.url?scp=84879088542&partnerID=8YFLogxK

U2 - 10.1021/nl400586t

DO - 10.1021/nl400586t

M3 - Article

C2 - 23634882

AN - SCOPUS:84879088542

SN - 1530-6984

VL - 13

SP - 2528

EP - 2534

JO - Nano Letters

JF - Nano Letters

IS - 6

ER -

Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this