Formation and characterization of light-responsive TEMPO-oxidized konjac glucomannan microspheres

Xiaodong Chen; Shanshan Wang; Meiling Lu; Yuying Chen; Luhai Zhao; Wei Li; Qipeng Yuan; Willem Norde; Yuan Li

doi:10.1021/bm500327m

Formation and characterization of light-responsive TEMPO-oxidized konjac glucomannan microspheres

Xiaodong Chen, Shanshan Wang, Meiling Lu, Yuying Chen, Luhai Zhao, Wei Li, Qipeng Yuan, Willem Norde, Yuan Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

A light-responsive delivery system has been developed. It consists of gelly microspheres made of TEMPO-oxidized Konjac glucomannan (OKGM) polymers where the carboxyl (COO^-) groups are cross-linked via ferric ions (Fe ³⁺) and in which functional ingredients may be incorporated. By irradiation with (simulated) sunlight, the microspheres degrade, thereby releasing the encapsulated component(s). The degree of oxidation (DO) of the OKGM polymers could be well-controlled between 15 and 80%, as confirmed by proton titrations and FT-IR spectroscopy. OKGM of DO 80% was selected to prepare the microspheres because the high COO^- content leads to a high density of cross-links, yielding a strong gel. The electrokinetic potential of the OKGM particles increases with increasing pH and decreasing salt concentration. Mössbauer and FT-IR spectroscopy revealed that the cross-links are formed through two modes of COO^--Fe³⁺ coordination, that is, 68.4% by bridging and 31.6% by unidentate binding. Thus, the unique properties of the OKGM microspheres make them potentially applicable as light-controlled biocompatible delivery systems.

Original language	English
Pages (from-to)	2166-2171
Number of pages	6
Journal	Biomacromolecules
Volume	15
Issue number	6
DOIs	https://doi.org/10.1021/bm500327m
Publication status	Published - 9 Jun 2014
Externally published	Yes

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title = "Formation and characterization of light-responsive TEMPO-oxidized konjac glucomannan microspheres",

abstract = "A light-responsive delivery system has been developed. It consists of gelly microspheres made of TEMPO-oxidized Konjac glucomannan (OKGM) polymers where the carboxyl (COO-) groups are cross-linked via ferric ions (Fe 3+) and in which functional ingredients may be incorporated. By irradiation with (simulated) sunlight, the microspheres degrade, thereby releasing the encapsulated component(s). The degree of oxidation (DO) of the OKGM polymers could be well-controlled between 15 and 80%, as confirmed by proton titrations and FT-IR spectroscopy. OKGM of DO 80% was selected to prepare the microspheres because the high COO- content leads to a high density of cross-links, yielding a strong gel. The electrokinetic potential of the OKGM particles increases with increasing pH and decreasing salt concentration. M{\"o}ssbauer and FT-IR spectroscopy revealed that the cross-links are formed through two modes of COO--Fe3+ coordination, that is, 68.4% by bridging and 31.6% by unidentate binding. Thus, the unique properties of the OKGM microspheres make them potentially applicable as light-controlled biocompatible delivery systems.",

author = "Xiaodong Chen and Shanshan Wang and Meiling Lu and Yuying Chen and Luhai Zhao and Wei Li and Qipeng Yuan and Willem Norde and Yuan Li",

year = "2014",

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doi = "10.1021/bm500327m",

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T1 - Formation and characterization of light-responsive TEMPO-oxidized konjac glucomannan microspheres

AU - Chen, Xiaodong

AU - Wang, Shanshan

AU - Lu, Meiling

AU - Chen, Yuying

AU - Zhao, Luhai

AU - Li, Wei

AU - Yuan, Qipeng

AU - Norde, Willem

AU - Li, Yuan

PY - 2014/6/9

Y1 - 2014/6/9

N2 - A light-responsive delivery system has been developed. It consists of gelly microspheres made of TEMPO-oxidized Konjac glucomannan (OKGM) polymers where the carboxyl (COO-) groups are cross-linked via ferric ions (Fe 3+) and in which functional ingredients may be incorporated. By irradiation with (simulated) sunlight, the microspheres degrade, thereby releasing the encapsulated component(s). The degree of oxidation (DO) of the OKGM polymers could be well-controlled between 15 and 80%, as confirmed by proton titrations and FT-IR spectroscopy. OKGM of DO 80% was selected to prepare the microspheres because the high COO- content leads to a high density of cross-links, yielding a strong gel. The electrokinetic potential of the OKGM particles increases with increasing pH and decreasing salt concentration. Mössbauer and FT-IR spectroscopy revealed that the cross-links are formed through two modes of COO--Fe3+ coordination, that is, 68.4% by bridging and 31.6% by unidentate binding. Thus, the unique properties of the OKGM microspheres make them potentially applicable as light-controlled biocompatible delivery systems.

AB - A light-responsive delivery system has been developed. It consists of gelly microspheres made of TEMPO-oxidized Konjac glucomannan (OKGM) polymers where the carboxyl (COO-) groups are cross-linked via ferric ions (Fe 3+) and in which functional ingredients may be incorporated. By irradiation with (simulated) sunlight, the microspheres degrade, thereby releasing the encapsulated component(s). The degree of oxidation (DO) of the OKGM polymers could be well-controlled between 15 and 80%, as confirmed by proton titrations and FT-IR spectroscopy. OKGM of DO 80% was selected to prepare the microspheres because the high COO- content leads to a high density of cross-links, yielding a strong gel. The electrokinetic potential of the OKGM particles increases with increasing pH and decreasing salt concentration. Mössbauer and FT-IR spectroscopy revealed that the cross-links are formed through two modes of COO--Fe3+ coordination, that is, 68.4% by bridging and 31.6% by unidentate binding. Thus, the unique properties of the OKGM microspheres make them potentially applicable as light-controlled biocompatible delivery systems.

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Formation and characterization of light-responsive TEMPO-oxidized konjac glucomannan microspheres

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