Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease

Jieling Qin; Misuk Cho; Youngkwan Lee

doi:10.1021/acsami.8b21425

Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease

Jieling Qin, Misuk Cho^*, Youngkwan Lee

^*Corresponding author for this work

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

In this work, the ferrocene-encapsulated Zn zeolitic imidazole framework (ZIF-8) was prepared by the self-assembly of Zn ions and 2-methylimidazole and used for the dual detection of amyloid-beta oligomers (AβO), which is the main neuropathological hallmark of Alzheimer's disease. Ferrocene is an optically and electrochemically active signal which was successfully encapsulated inside of the ZIF-8 and released by the competitive coordination between Zn ions and AβO after being treated with AβO. The released ferrocene content was monitored by ultraviolet/visible spectrophotometry and cyclic voltammetry. The dual determination of AβO played a synergetic role in the quick qualitative and precise quantitative analyses in a wide detection range of 10 ^-5 to 10 ² μM and good feasibility in artificial cerebrospinal fluid.

Original language	English
Pages (from-to)	11743-11748
Number of pages	6
Journal	ACS applied materials & interfaces
Volume	11
Issue number	12
DOIs	https://doi.org/10.1021/acsami.8b21425
Publication status	Published - 27 Mar 2019
Externally published	Yes

Keywords

ZIF-8
alzheimer's disease
amyloid beta
dual detection
ferrocene

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10.1021/acsami.8b21425

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title = "Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease",

abstract = " In this work, the ferrocene-encapsulated Zn zeolitic imidazole framework (ZIF-8) was prepared by the self-assembly of Zn ions and 2-methylimidazole and used for the dual detection of amyloid-beta oligomers (AβO), which is the main neuropathological hallmark of Alzheimer's disease. Ferrocene is an optically and electrochemically active signal which was successfully encapsulated inside of the ZIF-8 and released by the competitive coordination between Zn ions and AβO after being treated with AβO. The released ferrocene content was monitored by ultraviolet/visible spectrophotometry and cyclic voltammetry. The dual determination of AβO played a synergetic role in the quick qualitative and precise quantitative analyses in a wide detection range of 10 -5 to 10 2 μM and good feasibility in artificial cerebrospinal fluid.",

keywords = "ZIF-8, alzheimer's disease, amyloid beta, dual detection, ferrocene",

author = "Jieling Qin and Misuk Cho and Youngkwan Lee",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = mar,

day = "27",

doi = "10.1021/acsami.8b21425",

language = "English",

volume = "11",

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journal = "ACS applied materials & interfaces",

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publisher = "American Chemical Society",

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Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease. / Qin, Jieling; Cho, Misuk; Lee, Youngkwan.
In: ACS applied materials & interfaces, Vol. 11, No. 12, 27.03.2019, p. 11743-11748.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease

AU - Qin, Jieling

AU - Cho, Misuk

AU - Lee, Youngkwan

PY - 2019/3/27

Y1 - 2019/3/27

N2 - In this work, the ferrocene-encapsulated Zn zeolitic imidazole framework (ZIF-8) was prepared by the self-assembly of Zn ions and 2-methylimidazole and used for the dual detection of amyloid-beta oligomers (AβO), which is the main neuropathological hallmark of Alzheimer's disease. Ferrocene is an optically and electrochemically active signal which was successfully encapsulated inside of the ZIF-8 and released by the competitive coordination between Zn ions and AβO after being treated with AβO. The released ferrocene content was monitored by ultraviolet/visible spectrophotometry and cyclic voltammetry. The dual determination of AβO played a synergetic role in the quick qualitative and precise quantitative analyses in a wide detection range of 10 -5 to 10 2 μM and good feasibility in artificial cerebrospinal fluid.

AB - In this work, the ferrocene-encapsulated Zn zeolitic imidazole framework (ZIF-8) was prepared by the self-assembly of Zn ions and 2-methylimidazole and used for the dual detection of amyloid-beta oligomers (AβO), which is the main neuropathological hallmark of Alzheimer's disease. Ferrocene is an optically and electrochemically active signal which was successfully encapsulated inside of the ZIF-8 and released by the competitive coordination between Zn ions and AβO after being treated with AβO. The released ferrocene content was monitored by ultraviolet/visible spectrophotometry and cyclic voltammetry. The dual determination of AβO played a synergetic role in the quick qualitative and precise quantitative analyses in a wide detection range of 10 -5 to 10 2 μM and good feasibility in artificial cerebrospinal fluid.

KW - ZIF-8

KW - alzheimer's disease

KW - amyloid beta

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AN - SCOPUS:85063141952

SN - 1944-8244

VL - 11

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EP - 11748

JO - ACS applied materials & interfaces

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IS - 12

ER -

Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease

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Keywords

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