Facile and one-pot synthesis of 1,2-dihydroquinazolin-4(3H)-ones via tandem intramolecular pinner/dimroth rearrangement

Jian Hong Tang; Da Xin Shi; Li Jun Zhang; Qi Zhang; Jia Rong Li

doi:10.1080/00397910902908822

Facile and one-pot synthesis of 1,2-dihydroquinazolin-4(3H)-ones via tandem intramolecular pinner/dimroth rearrangement

Jian Hong Tang, Da Xin Shi, Li Jun Zhang, Qi Zhang, Jia Rong Li^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

An efficient synthetic method for the preparation of quinazolin-4-one derivatives was designed. The facile condensation of aromatic o-aminonitriles with aromatic aldehydes catalyzed by Lewis acid give 1,2-dihydroquinazolin-4(3H) -ones in moderate to good yields under refluxing dimethylformamide.

Original language	English
Pages (from-to)	632-641
Number of pages	10
Journal	Synthetic Communications
Volume	40
Issue number	5
DOIs	https://doi.org/10.1080/00397910902908822
Publication status	Published - Jan 2010

Keywords

Aromatic aldehyde
Aromatic o-aminonitrile
Catalyst
Cyclocondensation
One-pot synthesis

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10.1080/00397910902908822

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title = "Facile and one-pot synthesis of 1,2-dihydroquinazolin-4(3H)-ones via tandem intramolecular pinner/dimroth rearrangement",

abstract = "An efficient synthetic method for the preparation of quinazolin-4-one derivatives was designed. The facile condensation of aromatic o-aminonitriles with aromatic aldehydes catalyzed by Lewis acid give 1,2-dihydroquinazolin-4(3H) -ones in moderate to good yields under refluxing dimethylformamide.",

keywords = "Aromatic aldehyde, Aromatic o-aminonitrile, Catalyst, Cyclocondensation, One-pot synthesis",

author = "Tang, {Jian Hong} and Shi, {Da Xin} and Zhang, {Li Jun} and Qi Zhang and Li, {Jia Rong}",

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pages = "632--641",

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T1 - Facile and one-pot synthesis of 1,2-dihydroquinazolin-4(3H)-ones via tandem intramolecular pinner/dimroth rearrangement

AU - Tang, Jian Hong

AU - Shi, Da Xin

AU - Zhang, Li Jun

AU - Zhang, Qi

AU - Li, Jia Rong

PY - 2010/1

Y1 - 2010/1

N2 - An efficient synthetic method for the preparation of quinazolin-4-one derivatives was designed. The facile condensation of aromatic o-aminonitriles with aromatic aldehydes catalyzed by Lewis acid give 1,2-dihydroquinazolin-4(3H) -ones in moderate to good yields under refluxing dimethylformamide.

AB - An efficient synthetic method for the preparation of quinazolin-4-one derivatives was designed. The facile condensation of aromatic o-aminonitriles with aromatic aldehydes catalyzed by Lewis acid give 1,2-dihydroquinazolin-4(3H) -ones in moderate to good yields under refluxing dimethylformamide.

KW - Aromatic aldehyde

KW - Aromatic o-aminonitrile

KW - Catalyst

KW - Cyclocondensation

KW - One-pot synthesis

UR - http://www.scopus.com/inward/record.url?scp=76349100720&partnerID=8YFLogxK

U2 - 10.1080/00397910902908822

DO - 10.1080/00397910902908822

M3 - Article

AN - SCOPUS:76349100720

SN - 0039-7911

VL - 40

SP - 632

EP - 641

JO - Synthetic Communications

JF - Synthetic Communications

IS - 5

ER -

Facile and one-pot synthesis of 1,2-dihydroquinazolin-4(3H)-ones via tandem intramolecular pinner/dimroth rearrangement

Abstract

Keywords

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