@inproceedings{29950218c31048aead29c723fd5a97ab,
title = "Endoscope-based beveled and volume fiber-optic Raman probes for in vivo diagnosis of gastric dysplasia: A comparative study",
abstract = "Raman spectroscopy is a unique optical vibrational spectroscopic technique which is capable of probing biochemical and biomolecular structures and conformations associated with disease transformation. Raman probe is a key component to facilitate the in vivo tissue diagnosis by using Raman spectroscopy. The diagnostic performance of the two different endoscope-based fiber-optic Raman probe designs (i.e., beveled and volume Raman probes) were evaluated for real-time, in vivo diagnosis of gastric dysplasia at endoscopy. The beveled Raman probe provides approximately 2-fold improvements in tissue Raman to autofluorescence intensity ratios as compared to the use of volume Raman probe. The diagnostic accuracy of gastric dysplasia using beveled Raman probe is 93.0% (sensitivity of 92.5%; specificity of 93.1%), which is superior to the diagnostic performance (accuracy of 88.4%; sensitivity of 85.8%; specificity of 88.6%) using the volume Raman probe. Biomolecular modeling is finally employed to extract the different Raman active components interrogated by the two types of endoscope-based Raman probes.",
keywords = "Endoscopy, Fiber-optic Raman probe, Gastric dysplasia, In vivo optical diagnosis, Raman spectroscopy",
author = "Jianfeng Wang and Kan Lin and Wei Zheng and Ho, {Khek Yu} and Ming Teh and Yeoh, {Khay Guan} and Zhiwei Huang",
note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry ; Conference date: 13-02-2016 Through 14-02-2016",
year = "2016",
doi = "10.1117/12.2212067",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Anita Mahadevan-Jansen and Wolfgang Petrich",
booktitle = "Biomedical Vibrational Spectroscopy 2016",
address = "United States",
}