Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral lewis acid and achiral N-oxide catalysts

Fuxue Chen; Xiaoming Feng; Bo Qin; Guolin Zhang; Yaozhong Jiang

doi:10.1021/ol034158a

Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral lewis acid and achiral N-oxide catalysts

Fuxue Chen, Xiaoming Feng^*, Bo Qin, Guolin Zhang, Yaozhong Jiang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

131 Citations (Scopus)

Abstract

(Matrix presented). Enantioselective addition of TMSCN to ketones is achieved by a catalytic double-activation method using 1a-Ti(IV) complex as the Lewis acid and achiral N-oxide 2 as the Lewis base to activate ketones and TMSCN, respectively.

Original language	English
Pages (from-to)	949-952
Number of pages	4
Journal	Organic Letters
Volume	5
Issue number	6
DOIs	https://doi.org/10.1021/ol034158a
Publication status	Published - 20 Mar 2003
Externally published	Yes

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@article{33074f01fcbb4f8fa66669876200b859,

title = "Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral lewis acid and achiral N-oxide catalysts",

abstract = "(Matrix presented). Enantioselective addition of TMSCN to ketones is achieved by a catalytic double-activation method using 1a-Ti(IV) complex as the Lewis acid and achiral N-oxide 2 as the Lewis base to activate ketones and TMSCN, respectively.",

author = "Fuxue Chen and Xiaoming Feng and Bo Qin and Guolin Zhang and Yaozhong Jiang",

year = "2003",

month = mar,

day = "20",

doi = "10.1021/ol034158a",

language = "English",

volume = "5",

pages = "949--952",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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T1 - Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral lewis acid and achiral N-oxide catalysts

AU - Chen, Fuxue

AU - Feng, Xiaoming

AU - Qin, Bo

AU - Zhang, Guolin

AU - Jiang, Yaozhong

PY - 2003/3/20

Y1 - 2003/3/20

N2 - (Matrix presented). Enantioselective addition of TMSCN to ketones is achieved by a catalytic double-activation method using 1a-Ti(IV) complex as the Lewis acid and achiral N-oxide 2 as the Lewis base to activate ketones and TMSCN, respectively.

AB - (Matrix presented). Enantioselective addition of TMSCN to ketones is achieved by a catalytic double-activation method using 1a-Ti(IV) complex as the Lewis acid and achiral N-oxide 2 as the Lewis base to activate ketones and TMSCN, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0042681991&partnerID=8YFLogxK

U2 - 10.1021/ol034158a

DO - 10.1021/ol034158a

M3 - Article

C2 - 12633113

AN - SCOPUS:0042681991

SN - 1523-7060

VL - 5

SP - 949

EP - 952

JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral lewis acid and achiral N-oxide catalysts

Abstract

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