Electrically Controlled Tunable Broadband Interferometric Dielectric Spectroscopy: Groundwork for Single Cell Analysis

Meng Zhang, Ilja Ocket, Pawel Barmuta, Juncheng Bao, Xiue Bao, Hui Yang, Bart Nauwelaers

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

An electrically controlled tunable interference based microwave sensor is demonstrated to perform time domain detection of single particles and measure complex permittivity of cell culture mediums within the broadband range of 12-18 GHz. Following set up is required to construct deep destructive interference nulls. Quadrature hybrid (QH), voltage controlled phase shifter and attenuator are utilized for each of the two branches. These comprise a reference branch and a branch containing the material-under-test (MUT). Coplanar waveguide (CPW) design was used as the microwave sensing structure and microfluidic wells were manufactured with polydimethylsiloxane (PDMS) to contain MUT, reference and calibration materials. The capability of detecting a single particle (diameter of 6-6.4um) is reported compared to simulations. Cell culture mediums measurements of Luria Agar (LA) and Luria Broth (LB) medium over the above-mentioned bandwidth were performed to demonstrate the operation processes and lay the groundwork for future research.

Original languageEnglish
Title of host publication2019 49th European Microwave Conference, EuMC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages650-653
Number of pages4
ISBN (Electronic)9782874870552
DOIs
Publication statusPublished - Oct 2019
Externally publishedYes
Event49th European Microwave Conference, EuMC 2019 - Paris, France
Duration: 1 Oct 20193 Oct 2019

Publication series

Name2019 49th European Microwave Conference, EuMC 2019

Conference

Conference49th European Microwave Conference, EuMC 2019
Country/TerritoryFrance
CityParis
Period1/10/193/10/19

Keywords

  • complex dielectric permittivity
  • dielectric spectroscopy
  • interferometry sensor
  • microfluidics
  • microwave sensor

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