Effect of Baogan Yihao on liver fibrosis in rats induced by CCl4 and high-fat feeding

Wei Wei Meng; Nan Guo; Fan Kai Lin; Hai Wei Zhao; Yu Lin Deng; Rong Ji Dai; Yan Chen; Yu Mei Huang; Ying Hong Zhao

Effect of Baogan Yihao on liver fibrosis in rats induced by CCl₄ and high-fat feeding

Wei Wei Meng^*, Nan Guo, Fan Kai Lin, Hai Wei Zhao, Yu Lin Deng, Rong Ji Dai, Yan Chen, Yu Mei Huang, Ying Hong Zhao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The effect of Baogan Yihao (BGYH) on hepatic fibrosis induced by carbon tetrachloride (CCl₄) and high fat diet in rats was studied in this paper. Liver fibrosis was induced by CCl₄-soybean and high fat diet for 6 weeks, and BGYH preparation (600 mg/mL, 300 mg/kg, 150 mg/kg) was administered to the model group for 17 days. The results show that BGYH relieved fatty degeneration and hyperplasia in liver. BGYH can lower aspartate aminotransferase (AST), alanine aminotransferase (ALT), increase serum albumin (ALB), reduce the hyaluronic acid (HA), hydroxyproline (Hyp) and type I collagen protein (Col I) in livers. BGYH can lower transaminase level, improve liver function, reduce steatosis and fibrosis in liver. Therefore, BGYH has a significant effect on liver fibrosis.

Original language	English
Pages (from-to)	767-770
Number of pages	4
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	34
Issue number	7
Publication status	Published - 1 Jul 2014

Keywords

Baogan Yihao
Carbon tetrachloride
Hepatic fibrosis
High fat diet

Cite this

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title = "Effect of Baogan Yihao on liver fibrosis in rats induced by CCl4 and high-fat feeding",

abstract = "The effect of Baogan Yihao (BGYH) on hepatic fibrosis induced by carbon tetrachloride (CCl4) and high fat diet in rats was studied in this paper. Liver fibrosis was induced by CCl4-soybean and high fat diet for 6 weeks, and BGYH preparation (600 mg/mL, 300 mg/kg, 150 mg/kg) was administered to the model group for 17 days. The results show that BGYH relieved fatty degeneration and hyperplasia in liver. BGYH can lower aspartate aminotransferase (AST), alanine aminotransferase (ALT), increase serum albumin (ALB), reduce the hyaluronic acid (HA), hydroxyproline (Hyp) and type I collagen protein (Col I) in livers. BGYH can lower transaminase level, improve liver function, reduce steatosis and fibrosis in liver. Therefore, BGYH has a significant effect on liver fibrosis.",

keywords = "Baogan Yihao, Carbon tetrachloride, Hepatic fibrosis, High fat diet",

author = "Meng, {Wei Wei} and Nan Guo and Lin, {Fan Kai} and Zhao, {Hai Wei} and Deng, {Yu Lin} and Dai, {Rong Ji} and Yan Chen and Huang, {Yu Mei} and Zhao, {Ying Hong}",

year = "2014",

month = jul,

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language = "English",

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pages = "767--770",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

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TY - JOUR

T1 - Effect of Baogan Yihao on liver fibrosis in rats induced by CCl4 and high-fat feeding

AU - Meng, Wei Wei

AU - Guo, Nan

AU - Lin, Fan Kai

AU - Zhao, Hai Wei

AU - Deng, Yu Lin

AU - Dai, Rong Ji

AU - Chen, Yan

AU - Huang, Yu Mei

AU - Zhao, Ying Hong

PY - 2014/7/1

Y1 - 2014/7/1

N2 - The effect of Baogan Yihao (BGYH) on hepatic fibrosis induced by carbon tetrachloride (CCl4) and high fat diet in rats was studied in this paper. Liver fibrosis was induced by CCl4-soybean and high fat diet for 6 weeks, and BGYH preparation (600 mg/mL, 300 mg/kg, 150 mg/kg) was administered to the model group for 17 days. The results show that BGYH relieved fatty degeneration and hyperplasia in liver. BGYH can lower aspartate aminotransferase (AST), alanine aminotransferase (ALT), increase serum albumin (ALB), reduce the hyaluronic acid (HA), hydroxyproline (Hyp) and type I collagen protein (Col I) in livers. BGYH can lower transaminase level, improve liver function, reduce steatosis and fibrosis in liver. Therefore, BGYH has a significant effect on liver fibrosis.

AB - The effect of Baogan Yihao (BGYH) on hepatic fibrosis induced by carbon tetrachloride (CCl4) and high fat diet in rats was studied in this paper. Liver fibrosis was induced by CCl4-soybean and high fat diet for 6 weeks, and BGYH preparation (600 mg/mL, 300 mg/kg, 150 mg/kg) was administered to the model group for 17 days. The results show that BGYH relieved fatty degeneration and hyperplasia in liver. BGYH can lower aspartate aminotransferase (AST), alanine aminotransferase (ALT), increase serum albumin (ALB), reduce the hyaluronic acid (HA), hydroxyproline (Hyp) and type I collagen protein (Col I) in livers. BGYH can lower transaminase level, improve liver function, reduce steatosis and fibrosis in liver. Therefore, BGYH has a significant effect on liver fibrosis.

KW - Baogan Yihao

KW - Carbon tetrachloride

KW - Hepatic fibrosis

KW - High fat diet

UR - http://www.scopus.com/inward/record.url?scp=84907758059&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84907758059

SN - 1001-0645

VL - 34

SP - 767

EP - 770

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 7

ER -

Effect of Baogan Yihao on liver fibrosis in rats induced by CCl₄ and high-fat feeding

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