Dynamic model of vascular-targeted photodynamic therapy

Xiao Ming Hu; Linhuan He; Yi Zhao

doi:10.1080/10255842.2017.1331344

Dynamic model of vascular-targeted photodynamic therapy

Xiao Ming Hu^*, Linhuan He, Yi Zhao

^*Corresponding author for this work

School of Medical and Technology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation. Therefore, the optimized treatment protocol may involve a balance among the phototoxicity, hypoxia, and photothermolysis.

Original language	English
Pages (from-to)	1056-1065
Number of pages	10
Journal	Computer Methods in Biomechanics and Biomedical Engineering
Volume	20
Issue number	10
DOIs	https://doi.org/10.1080/10255842.2017.1331344
Publication status	Published - 27 Jul 2017

Keywords

Photodynamic therapy
computer simulation
hypoxia
photothermolysis
singlet oxygen

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10.1080/10255842.2017.1331344

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title = "Dynamic model of vascular-targeted photodynamic therapy",

abstract = "Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation. Therefore, the optimized treatment protocol may involve a balance among the phototoxicity, hypoxia, and photothermolysis.",

keywords = "Photodynamic therapy, computer simulation, hypoxia, photothermolysis, singlet oxygen",

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T1 - Dynamic model of vascular-targeted photodynamic therapy

AU - Hu, Xiao Ming

AU - He, Linhuan

AU - Zhao, Yi

PY - 2017/7/27

Y1 - 2017/7/27

N2 - Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation. Therefore, the optimized treatment protocol may involve a balance among the phototoxicity, hypoxia, and photothermolysis.

AB - Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation. Therefore, the optimized treatment protocol may involve a balance among the phototoxicity, hypoxia, and photothermolysis.

KW - Photodynamic therapy

KW - computer simulation

KW - hypoxia

KW - photothermolysis

KW - singlet oxygen

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JF - Computer Methods in Biomechanics and Biomedical Engineering

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Dynamic model of vascular-targeted photodynamic therapy

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Keywords

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