Dual responsive supramolecular nanogels for intracellular drug delivery

Xiaofei Chen; Li Chen; Xuemei Yao; Zhe Zhang; Chaoliang He; Jingping Zhang; Xuesi Chen

doi:10.1039/c4cc00016a

Dual responsive supramolecular nanogels for intracellular drug delivery

Xiaofei Chen, Li Chen^*, Xuemei Yao, Zhe Zhang, Chaoliang He, Jingping Zhang, Xuesi Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

Original language	English
Pages (from-to)	3789-3791
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	29
DOIs	https://doi.org/10.1039/c4cc00016a
Publication status	Published - 13 Mar 2014
Externally published	Yes

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10.1039/c4cc00016a

Cite this

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abstract = "Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.",

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AU - Chen, Xiaofei

AU - Chen, Li

AU - Yao, Xuemei

AU - Zhang, Zhe

AU - He, Chaoliang

AU - Zhang, Jingping

AU - Chen, Xuesi

PY - 2014/3/13

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AB - Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

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DO - 10.1039/c4cc00016a

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JO - Chemical Communications

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ER -

Dual responsive supramolecular nanogels for intracellular drug delivery

Abstract

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