Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

Baoquan Che; Lin Wang; Zhe Zhang; Yongqian Zhang; Yulin Deng

doi:10.1016/j.neuro.2012.07.004

Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

Baoquan Che, Lin Wang, Zhe Zhang, Yongqian Zhang, Yulin Deng^*

^*Corresponding author for this work

School of Medical and Technology

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.

Original language	English
Pages (from-to)	1248-1253
Number of pages	6
Journal	NeuroToxicology
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.neuro.2012.07.004
Publication status	Published - Oct 2012

Keywords

Accumulation
Caffeine
Distribution
Inhibitor
SSAO

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10.1016/j.neuro.2012.07.004

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abstract = "Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.",

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AU - Che, Baoquan

AU - Wang, Lin

AU - Zhang, Zhe

AU - Zhang, Yongqian

AU - Deng, Yulin

PY - 2012/10

Y1 - 2012/10

N2 - Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.

AB - Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.

KW - Accumulation

KW - Caffeine

KW - Distribution

KW - Inhibitor

KW - SSAO

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Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

Abstract

Keywords

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