Zhao, L., Deng, X., Ding, N., Liu, Y., Ma, Y., Li, J., Wang, S., Ji, X., Wang, J., Wang, D., Li, Y., Dou, D., Zhu, X., Zhu, L., & Zhang, S. (2024). Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty. iScience, 27(8), Article 110403. https://doi.org/10.1016/j.isci.2024.110403
Zhao, Luqing ; Deng, Xin ; Ding, Ning et al. / Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty. In: iScience. 2024 ; Vol. 27, No. 8.
@article{588b66133c024d2ea63682bf280fc1e0,
title = "Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty",
abstract = "Constipation and frailty are associated with intestinal dysbiosis. This study aims to identify intestinal microbial signatures that can differentiate between constipated elders accompanied by frailty and those without frailty. We collected stool samples from 61 participants and conducted 16S rRNA gene sequencing. Constipated patients with frailty (Constipation_F) exhibited reduced gut microbial diversities compared to constipated patients without frailty (Constipation_NF) and healthy individuals (C). From differential genera, random forest models identified 14, 8, and 5 biomarkers for distinguishing Constipation_F from Constipation_NF, Constipation_F from C, and Constipation_NF from C, respectively. Functional analysis revealed that pathways (P381-PWY and PWY-5507) related to vitamin B12 synthesis were reduced in Constipation_F, which aligns with the decreased abundances of vitamin-B12-producing Actinomyces and Akkermansia in this group. Our study unveils substantial differences in gut microbiota between constipated elders with frailty and those without, underscoring the diagnostic and therapeutic potential of genera involved in vitamin B12 synthesis.",
keywords = "Microbial metabolism, Microbiology",
author = "Luqing Zhao and Xin Deng and Ning Ding and Yanzhen Liu and Yun Ma and Jiake Li and Shuqing Wang and Xingyu Ji and Jinjuan Wang and Dianpeng Wang and Yanhui Li and Dan Dou and Xihan Zhu and Lixin Zhu and Shengsheng Zhang",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors",
year = "2024",
month = aug,
day = "16",
doi = "10.1016/j.isci.2024.110403",
language = "English",
volume = "27",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "8",
}
Zhao, L, Deng, X, Ding, N, Liu, Y, Ma, Y, Li, J, Wang, S, Ji, X, Wang, J, Wang, D, Li, Y, Dou, D, Zhu, X, Zhu, L & Zhang, S 2024, 'Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty', iScience, vol. 27, no. 8, 110403. https://doi.org/10.1016/j.isci.2024.110403
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty. / Zhao, Luqing; Deng, Xin; Ding, Ning et al.
In:
iScience, Vol. 27, No. 8, 110403, 16.08.2024.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty
AU - Zhao, Luqing
AU - Deng, Xin
AU - Ding, Ning
AU - Liu, Yanzhen
AU - Ma, Yun
AU - Li, Jiake
AU - Wang, Shuqing
AU - Ji, Xingyu
AU - Wang, Jinjuan
AU - Wang, Dianpeng
AU - Li, Yanhui
AU - Dou, Dan
AU - Zhu, Xihan
AU - Zhu, Lixin
AU - Zhang, Shengsheng
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/8/16
Y1 - 2024/8/16
N2 - Constipation and frailty are associated with intestinal dysbiosis. This study aims to identify intestinal microbial signatures that can differentiate between constipated elders accompanied by frailty and those without frailty. We collected stool samples from 61 participants and conducted 16S rRNA gene sequencing. Constipated patients with frailty (Constipation_F) exhibited reduced gut microbial diversities compared to constipated patients without frailty (Constipation_NF) and healthy individuals (C). From differential genera, random forest models identified 14, 8, and 5 biomarkers for distinguishing Constipation_F from Constipation_NF, Constipation_F from C, and Constipation_NF from C, respectively. Functional analysis revealed that pathways (P381-PWY and PWY-5507) related to vitamin B12 synthesis were reduced in Constipation_F, which aligns with the decreased abundances of vitamin-B12-producing Actinomyces and Akkermansia in this group. Our study unveils substantial differences in gut microbiota between constipated elders with frailty and those without, underscoring the diagnostic and therapeutic potential of genera involved in vitamin B12 synthesis.
AB - Constipation and frailty are associated with intestinal dysbiosis. This study aims to identify intestinal microbial signatures that can differentiate between constipated elders accompanied by frailty and those without frailty. We collected stool samples from 61 participants and conducted 16S rRNA gene sequencing. Constipated patients with frailty (Constipation_F) exhibited reduced gut microbial diversities compared to constipated patients without frailty (Constipation_NF) and healthy individuals (C). From differential genera, random forest models identified 14, 8, and 5 biomarkers for distinguishing Constipation_F from Constipation_NF, Constipation_F from C, and Constipation_NF from C, respectively. Functional analysis revealed that pathways (P381-PWY and PWY-5507) related to vitamin B12 synthesis were reduced in Constipation_F, which aligns with the decreased abundances of vitamin-B12-producing Actinomyces and Akkermansia in this group. Our study unveils substantial differences in gut microbiota between constipated elders with frailty and those without, underscoring the diagnostic and therapeutic potential of genera involved in vitamin B12 synthesis.
KW - Microbial metabolism
KW - Microbiology
UR - http://www.scopus.com/inward/record.url?scp=85198160796&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2024.110403
DO - 10.1016/j.isci.2024.110403
M3 - Article
AN - SCOPUS:85198160796
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 8
M1 - 110403
ER -
Zhao L, Deng X, Ding N, Liu Y, Ma Y, Li J et al. Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty. iScience. 2024 Aug 16;27(8):110403. doi: 10.1016/j.isci.2024.110403
