Delivery of siRNA using cationic liposomes incorporating stearic acid-modified octa-arginine

Dongsheng Yang; Yuhuan Li; Yuhang Qi; Yongzhen Chen; Xuewei Yang; Yujing Li; Songcai Liu; Robert J. Lee

Delivery of siRNA using cationic liposomes incorporating stearic acid-modified octa-arginine

Dongsheng Yang, Yuhuan Li, Yuhang Qi, Yongzhen Chen, Xuewei Yang, Yujing Li, Songcai Liu^*, Robert J. Lee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Cationic liposomes incorporating stearic acidmodified octa-arginine (StA-R8) were evaluated for survivin small interfering RNA (siRNA) delivery. StA-R8 was synthesized and incorporated into liposomes. The composition of liposomes was optimized. Physicochemical properties, cytotoxicity, cellular uptake and gene silencing activity of the liposomes complexed to survivin siRNA were investigated. The results showed that StA-R8-containing liposomes had reduced cytotoxicity and improved delivery efficiency of siRNA into cancer cells compared with StA-R8 by itself.

Original language	English
Pages (from-to)	3271-3276
Number of pages	6
Journal	Anticancer Research
Volume	36
Issue number	7
Publication status	Published - 2016
Externally published	Yes

Keywords

Cancer
Cationic liposomes
Cell-penetrating peptide
Octa-arginine
Survivin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Delivery of siRNA using cationic liposomes incorporating stearic acid-modified octa-arginine",

abstract = "Cationic liposomes incorporating stearic acidmodified octa-arginine (StA-R8) were evaluated for survivin small interfering RNA (siRNA) delivery. StA-R8 was synthesized and incorporated into liposomes. The composition of liposomes was optimized. Physicochemical properties, cytotoxicity, cellular uptake and gene silencing activity of the liposomes complexed to survivin siRNA were investigated. The results showed that StA-R8-containing liposomes had reduced cytotoxicity and improved delivery efficiency of siRNA into cancer cells compared with StA-R8 by itself.",

keywords = "Cancer, Cationic liposomes, Cell-penetrating peptide, Octa-arginine, Survivin",

author = "Dongsheng Yang and Yuhuan Li and Yuhang Qi and Yongzhen Chen and Xuewei Yang and Yujing Li and Songcai Liu and Lee, {Robert J.}",

year = "2016",

language = "English",

volume = "36",

pages = "3271--3276",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "7",

}

TY - JOUR

T1 - Delivery of siRNA using cationic liposomes incorporating stearic acid-modified octa-arginine

AU - Yang, Dongsheng

AU - Li, Yuhuan

AU - Qi, Yuhang

AU - Chen, Yongzhen

AU - Yang, Xuewei

AU - Li, Yujing

AU - Liu, Songcai

AU - Lee, Robert J.

PY - 2016

Y1 - 2016

N2 - Cationic liposomes incorporating stearic acidmodified octa-arginine (StA-R8) were evaluated for survivin small interfering RNA (siRNA) delivery. StA-R8 was synthesized and incorporated into liposomes. The composition of liposomes was optimized. Physicochemical properties, cytotoxicity, cellular uptake and gene silencing activity of the liposomes complexed to survivin siRNA were investigated. The results showed that StA-R8-containing liposomes had reduced cytotoxicity and improved delivery efficiency of siRNA into cancer cells compared with StA-R8 by itself.

AB - Cationic liposomes incorporating stearic acidmodified octa-arginine (StA-R8) were evaluated for survivin small interfering RNA (siRNA) delivery. StA-R8 was synthesized and incorporated into liposomes. The composition of liposomes was optimized. Physicochemical properties, cytotoxicity, cellular uptake and gene silencing activity of the liposomes complexed to survivin siRNA were investigated. The results showed that StA-R8-containing liposomes had reduced cytotoxicity and improved delivery efficiency of siRNA into cancer cells compared with StA-R8 by itself.

KW - Cancer

KW - Cationic liposomes

KW - Cell-penetrating peptide

KW - Octa-arginine

KW - Survivin

UR - http://www.scopus.com/inward/record.url?scp=84992144582&partnerID=8YFLogxK

M3 - Article

C2 - 27354583

AN - SCOPUS:84992144582

SN - 0250-7005

VL - 36

SP - 3271

EP - 3276

JO - Anticancer Research

JF - Anticancer Research

IS - 7

ER -

Delivery of siRNA using cationic liposomes incorporating stearic acid-modified octa-arginine

Abstract

Keywords

UN SDGs

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