Curcumin-based electrochemical sensor of amyloid-Β oligomer for the early detection of Alzheimer's disease

Jieling Qin; Jin Su Park; Dong Gyu Jo; Misuk Cho; Youngkwan Lee

doi:10.1016/j.snb.2018.07.078

Curcumin-based electrochemical sensor of amyloid-Β oligomer for the early detection of Alzheimer's disease

Jieling Qin, Jin Su Park, Dong Gyu Jo, Misuk Cho^*, Youngkwan Lee

^*Corresponding author for this work

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Amyloid β oligomer (AβO) is a promising biomarker with potential to diagnose the Alzheimer's disease (AD). To detect the low level of AβO is highly desirable for the early diagnosis of AD. Here we describe the fabrication and sensing performance of curcumin based AβO sensor. Curcumin-Ni was electropolymerized on Ni foam substrate, and the surface resistance change of the poly(curcumin-Ni) electrode depending on AβO concentration was confirmed by electrochemical impedance spectroscopy. The impedance response of the curcumin based sensor showed a proportional relationship with the concentrations of AβO in the range from 0.001 to 5 nM. The feasibility of the sensor was verified by the detection of AβO in artificial cerebrospinal fluid. The proposed AβO sensor presents valuable information related to early diagnosis of AD.

Original language	English
Pages (from-to)	1593-1599
Number of pages	7
Journal	Sensors and Actuators, B: Chemical
Volume	273
DOIs	https://doi.org/10.1016/j.snb.2018.07.078
Publication status	Published - 10 Nov 2018
Externally published	Yes

Keywords

Alzheimer's disease
Amyloid beta
Impedance sensor
Poly(curcumin-Ni)

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10.1016/j.snb.2018.07.078

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title = "Curcumin-based electrochemical sensor of amyloid-Β oligomer for the early detection of Alzheimer's disease",

abstract = "Amyloid β oligomer (AβO) is a promising biomarker with potential to diagnose the Alzheimer's disease (AD). To detect the low level of AβO is highly desirable for the early diagnosis of AD. Here we describe the fabrication and sensing performance of curcumin based AβO sensor. Curcumin-Ni was electropolymerized on Ni foam substrate, and the surface resistance change of the poly(curcumin-Ni) electrode depending on AβO concentration was confirmed by electrochemical impedance spectroscopy. The impedance response of the curcumin based sensor showed a proportional relationship with the concentrations of AβO in the range from 0.001 to 5 nM. The feasibility of the sensor was verified by the detection of AβO in artificial cerebrospinal fluid. The proposed AβO sensor presents valuable information related to early diagnosis of AD.",

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T1 - Curcumin-based electrochemical sensor of amyloid-Β oligomer for the early detection of Alzheimer's disease

AU - Qin, Jieling

AU - Park, Jin Su

AU - Jo, Dong Gyu

AU - Cho, Misuk

AU - Lee, Youngkwan

PY - 2018/11/10

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N2 - Amyloid β oligomer (AβO) is a promising biomarker with potential to diagnose the Alzheimer's disease (AD). To detect the low level of AβO is highly desirable for the early diagnosis of AD. Here we describe the fabrication and sensing performance of curcumin based AβO sensor. Curcumin-Ni was electropolymerized on Ni foam substrate, and the surface resistance change of the poly(curcumin-Ni) electrode depending on AβO concentration was confirmed by electrochemical impedance spectroscopy. The impedance response of the curcumin based sensor showed a proportional relationship with the concentrations of AβO in the range from 0.001 to 5 nM. The feasibility of the sensor was verified by the detection of AβO in artificial cerebrospinal fluid. The proposed AβO sensor presents valuable information related to early diagnosis of AD.

AB - Amyloid β oligomer (AβO) is a promising biomarker with potential to diagnose the Alzheimer's disease (AD). To detect the low level of AβO is highly desirable for the early diagnosis of AD. Here we describe the fabrication and sensing performance of curcumin based AβO sensor. Curcumin-Ni was electropolymerized on Ni foam substrate, and the surface resistance change of the poly(curcumin-Ni) electrode depending on AβO concentration was confirmed by electrochemical impedance spectroscopy. The impedance response of the curcumin based sensor showed a proportional relationship with the concentrations of AβO in the range from 0.001 to 5 nM. The feasibility of the sensor was verified by the detection of AβO in artificial cerebrospinal fluid. The proposed AβO sensor presents valuable information related to early diagnosis of AD.

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KW - Amyloid beta

KW - Impedance sensor

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Curcumin-based electrochemical sensor of amyloid-Β oligomer for the early detection of Alzheimer's disease

Abstract

Keywords

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