TY - JOUR
T1 - CO2-switchable response of protein microtubules
T2 - Behaviour and mechanism
AU - Yang, Guang
AU - Hu, Rongting
AU - Ding, Hong Ming
AU - Kochovski, Zdravko
AU - Mei, Shilin
AU - Lu, Yan
AU - Ma, Yu Qiang
AU - Chen, Guosong
AU - Jiang, Ming
N1 - Publisher Copyright:
© 2018 the Partner Organisations.
PY - 2018/9
Y1 - 2018/9
N2 - Recently, we proposed a small molecular "inducing ligand" strategy to assemble proteins into highly-ordered structures via dual non-covalent interactions, i.e. carbohydrate-protein interaction and dimerization of Rhodamine B. Using this approach, artificial protein microtubules were successfully constructed. In this study, we find that these microtubules exhibit a perfect CO2 responsiveness; assembly and disassembly of these microtubules were nicely controlled by the alternative passage of CO2 and N2. Upon the injection of CO2, a negative net-charged SBA turns into a neutral or positive net-charged SBA, which elongated, to some extent, the effective distance between SBA and Rhodamine B, resulting in the disassociation of the Rhodamine B dimer. Further experimental and simulation results reveal that the CO2-responsive mechanism differs from that of solubility change of the previously reported CO2-responsive synthetic materials.
AB - Recently, we proposed a small molecular "inducing ligand" strategy to assemble proteins into highly-ordered structures via dual non-covalent interactions, i.e. carbohydrate-protein interaction and dimerization of Rhodamine B. Using this approach, artificial protein microtubules were successfully constructed. In this study, we find that these microtubules exhibit a perfect CO2 responsiveness; assembly and disassembly of these microtubules were nicely controlled by the alternative passage of CO2 and N2. Upon the injection of CO2, a negative net-charged SBA turns into a neutral or positive net-charged SBA, which elongated, to some extent, the effective distance between SBA and Rhodamine B, resulting in the disassociation of the Rhodamine B dimer. Further experimental and simulation results reveal that the CO2-responsive mechanism differs from that of solubility change of the previously reported CO2-responsive synthetic materials.
UR - http://www.scopus.com/inward/record.url?scp=85052572176&partnerID=8YFLogxK
U2 - 10.1039/c8qm00245b
DO - 10.1039/c8qm00245b
M3 - Article
AN - SCOPUS:85052572176
SN - 2052-1537
VL - 2
SP - 1642
EP - 1646
JO - Materials Chemistry Frontiers
JF - Materials Chemistry Frontiers
IS - 9
ER -