Compact Raman needle probe with fine needle aspiration biopsy for solid tissues

Jianfeng Wang, Wei Zheng, Zhiwei Huang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Raman spectroscopy represents a label-free vibrational spectroscopic technique for studying the biochemical and biomolecular compositions of human body. Raman probe is a key component to facilitate the in vivo diagnosis by using Raman spectroscopy. We investigated a compact Raman needle probe design to be integrated into a device that can also take biopsies of solid tissues for cytological assessment, enabling concurrent Raman spectroscopic interrogation and fine needle aspiration biopsy with a single needle penetration. We described the fabrication of the Raman needle probe and its assembly with the biopsy device. Example Raman spectra of various solid tissues are given.

Original languageEnglish
Title of host publicationOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XV
EditorsIsrael Gannot
PublisherSPIE
ISBN (Electronic)9781628414073
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XV - San Francisco, United States
Duration: 7 Feb 20158 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9317
ISSN (Print)1605-7422

Conference

ConferenceOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XV
Country/TerritoryUnited States
CitySan Francisco
Period7/02/158/02/15

Keywords

  • Fine needle aspiration
  • Raman needle probe
  • Solid tissue

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