Chitosan hydrogel in combination with marine peptides from tilapia for burns healing

Qian Qian Ouyang; Zhang Hu; Zhen Peng Lin; Wei Yan Quan; Yi Feng Deng; Si Dong Li; Pu Wang Li; Yu Chen

doi:10.1016/j.ijbiomac.2018.01.217

Chitosan hydrogel in combination with marine peptides from tilapia for burns healing

Qian Qian Ouyang, Zhang Hu, Zhen Peng Lin, Wei Yan Quan, Yi Feng Deng, Si Dong Li^*, Pu Wang Li, Yu Chen

^*Corresponding author for this work

School of Material Science and Engineering

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing.

Original language	English
Pages (from-to)	1191-1198
Number of pages	8
Journal	International Journal of Biological Macromolecules
Volume	112
DOIs	https://doi.org/10.1016/j.ijbiomac.2018.01.217
Publication status	Published - Jun 2018

Keywords

Burns healing
Chitosan
Marine peptides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijbiomac.2018.01.217

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@article{b28d8c094f5d48549ca947ac8086a394,

title = "Chitosan hydrogel in combination with marine peptides from tilapia for burns healing",

abstract = "The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing.",

keywords = "Burns healing, Chitosan, Marine peptides",

author = "Ouyang, {Qian Qian} and Zhang Hu and Lin, {Zhen Peng} and Quan, {Wei Yan} and Deng, {Yi Feng} and Li, {Si Dong} and Li, {Pu Wang} and Yu Chen",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = jun,

doi = "10.1016/j.ijbiomac.2018.01.217",

language = "English",

volume = "112",

pages = "1191--1198",

journal = "International Journal of Biological Macromolecules",

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T1 - Chitosan hydrogel in combination with marine peptides from tilapia for burns healing

AU - Ouyang, Qian Qian

AU - Hu, Zhang

AU - Lin, Zhen Peng

AU - Quan, Wei Yan

AU - Deng, Yi Feng

AU - Li, Si Dong

AU - Li, Pu Wang

AU - Chen, Yu

PY - 2018/6

Y1 - 2018/6

N2 - The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing.

AB - The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing.

KW - Burns healing

KW - Chitosan

KW - Marine peptides

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DO - 10.1016/j.ijbiomac.2018.01.217

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SN - 0141-8130

VL - 112

SP - 1191

EP - 1198

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

ER -

Chitosan hydrogel in combination with marine peptides from tilapia for burns healing

Abstract

Keywords

UN SDGs

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