Chitosan-based hydrogel dressings with antibacterial and antioxidant for wound healing

Yongyan Yang, Ying Ma, Haodong Wang, Chongruihan Li, Chaoqun Li, Ruiting Zhang, Shuangling Zhong, Wenqi He*, Xuejun Cui*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Bacterial infection and free radical oxidative stress at the wound site could easily cause cascade inflammation and hinder the healing process of the wound. In this study, chitosan-cysteine-gallic acid (CCG) hydrogel with antibacterial and antioxidant properties was synthesized by chitosan (CS), cysteine (Cys), and gallic acid (GA) for a preliminary evaluation of its therapeutic efficacy in a mouse model of full-layer skin defect. In vitro analysis showed that the CCG hydrogel had good antibacterial activity and blood compatibility. In vivo, the CCG hydrogel wound dressings accelerated wound healing, stimulate angiogenesis, increase collagen deposition and anti-inflammatory factor expression. The CCG hydrogel wound dressing is designed to promote the regeneration of damaged skin tissue and is expected to become a potential candidate for clinical treatment.

Original languageEnglish
Article number135939
JournalInternational Journal of Biological Macromolecules
Volume280
DOIs
Publication statusPublished - Nov 2024
Externally publishedYes

Keywords

  • Chitosan
  • Gallic acid
  • Hydrogel
  • Self-healing
  • Wound dressing

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Yang, Y., Ma, Y., Wang, H., Li, C., Li, C., Zhang, R., Zhong, S., He, W., & Cui, X. (2024). Chitosan-based hydrogel dressings with antibacterial and antioxidant for wound healing. International Journal of Biological Macromolecules, 280, Article 135939. https://doi.org/10.1016/j.ijbiomac.2024.135939