Chiral recognition and selection during the self-assembly process of protein-mimic macroanions

Panchao Yin; Zhi Ming Zhang; Hongjin Lv; Tao Li; Fadi Haso; Lang Hu; Baofang Zhang; John Bacsa; Yongge Wei; Yanqing Gao; Yu Hou; Yang Guang Li; Craig L. Hill; En Bo Wang; Tianbo Liu

doi:10.1038/ncomms7475

Chiral recognition and selection during the self-assembly process of protein-mimic macroanions

Panchao Yin, Zhi Ming Zhang, Hongjin Lv, Tao Li, Fadi Haso, Lang Hu, Baofang Zhang, John Bacsa, Yongge Wei, Yanqing Gao, Yu Hou, Yang Guang Li, Craig L. Hill, En Bo Wang^*, Tianbo Liu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

The research on chiral recognition and chiral selection is not only fundamental in resolving the puzzle of homochirality, but also instructive in chiral separation and stereoselective catalysis. Here we report the chiral recognition and chiral selection during the self-assembly process of two enantiomeric wheel-shaped macroanions, [Fe₂₈μ₃-O)₈ (Tart)₁₆ (HCOO)₂₄[^20- (Tart=D-or L-tartaric acid tetra-anion). The enantiomers are observed to remain self-sorted and self-assemble into their individual assemblies in their racemic mixture solution. The addition of chiral co-anions can selectively suppress the self-assembly process of the enantiomeric macroanions, which is further used to separate the two enantiomers from their mixtures on the basis of the size difference between the monomers and the assemblies. We believe that delicate long-range electrostatic interactions could be responsible for such high-level chiral recognition and selection.

Original language	English
Article number	6475
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms7475
Publication status	Published - 10 Mar 2015
Externally published	Yes

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title = "Chiral recognition and selection during the self-assembly process of protein-mimic macroanions",

abstract = "The research on chiral recognition and chiral selection is not only fundamental in resolving the puzzle of homochirality, but also instructive in chiral separation and stereoselective catalysis. Here we report the chiral recognition and chiral selection during the self-assembly process of two enantiomeric wheel-shaped macroanions, [Fe28μ3-O)8 (Tart)16 (HCOO)24[20- (Tart=D-or L-tartaric acid tetra-anion). The enantiomers are observed to remain self-sorted and self-assemble into their individual assemblies in their racemic mixture solution. The addition of chiral co-anions can selectively suppress the self-assembly process of the enantiomeric macroanions, which is further used to separate the two enantiomers from their mixtures on the basis of the size difference between the monomers and the assemblies. We believe that delicate long-range electrostatic interactions could be responsible for such high-level chiral recognition and selection.",

author = "Panchao Yin and Zhang, {Zhi Ming} and Hongjin Lv and Tao Li and Fadi Haso and Lang Hu and Baofang Zhang and John Bacsa and Yongge Wei and Yanqing Gao and Yu Hou and Li, {Yang Guang} and Hill, {Craig L.} and Wang, {En Bo} and Tianbo Liu",

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doi = "10.1038/ncomms7475",

language = "English",

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T1 - Chiral recognition and selection during the self-assembly process of protein-mimic macroanions

AU - Yin, Panchao

AU - Zhang, Zhi Ming

AU - Lv, Hongjin

AU - Li, Tao

AU - Haso, Fadi

AU - Hu, Lang

AU - Zhang, Baofang

AU - Bacsa, John

AU - Wei, Yongge

AU - Gao, Yanqing

AU - Hou, Yu

AU - Li, Yang Guang

AU - Hill, Craig L.

AU - Wang, En Bo

AU - Liu, Tianbo

PY - 2015/3/10

Y1 - 2015/3/10

N2 - The research on chiral recognition and chiral selection is not only fundamental in resolving the puzzle of homochirality, but also instructive in chiral separation and stereoselective catalysis. Here we report the chiral recognition and chiral selection during the self-assembly process of two enantiomeric wheel-shaped macroanions, [Fe28μ3-O)8 (Tart)16 (HCOO)24[20- (Tart=D-or L-tartaric acid tetra-anion). The enantiomers are observed to remain self-sorted and self-assemble into their individual assemblies in their racemic mixture solution. The addition of chiral co-anions can selectively suppress the self-assembly process of the enantiomeric macroanions, which is further used to separate the two enantiomers from their mixtures on the basis of the size difference between the monomers and the assemblies. We believe that delicate long-range electrostatic interactions could be responsible for such high-level chiral recognition and selection.

AB - The research on chiral recognition and chiral selection is not only fundamental in resolving the puzzle of homochirality, but also instructive in chiral separation and stereoselective catalysis. Here we report the chiral recognition and chiral selection during the self-assembly process of two enantiomeric wheel-shaped macroanions, [Fe28μ3-O)8 (Tart)16 (HCOO)24[20- (Tart=D-or L-tartaric acid tetra-anion). The enantiomers are observed to remain self-sorted and self-assemble into their individual assemblies in their racemic mixture solution. The addition of chiral co-anions can selectively suppress the self-assembly process of the enantiomeric macroanions, which is further used to separate the two enantiomers from their mixtures on the basis of the size difference between the monomers and the assemblies. We believe that delicate long-range electrostatic interactions could be responsible for such high-level chiral recognition and selection.

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DO - 10.1038/ncomms7475

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SN - 2041-1723

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JO - Nature Communications

JF - Nature Communications

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Chiral recognition and selection during the self-assembly process of protein-mimic macroanions

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